PanelApp (staging)
  1. Genes and Genomic Entities
  2. WARS

WARS

tryptophanyl-tRNA synthetase
OMIM: 191050, ClinGen, DECIPHER

5 panels

Panel Reviews Mode of inheritance Details
5 panels

Green WARS in Mendeliome


Version 1.2302

3 reviews BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Expert Review Green
  • Literature
Phenotypes
  • Neuronopathy, distal hereditary motor, type IX (OMIM:617721)
  • juvenile to adult onset (15-23 years)
  • Neurodevelopmental disorder withmicrocephaly and speech delay, with or without brain abnormalities, MIM# 620317

Green WARS in Microcephaly


Level 2: Dysmorphic and congenital abnormality syndromes
Version 1.295

2 reviews BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Literature
Phenotypes
  • Neurodevelopmental disorder withmicrocephaly and speech delay, with or without brain abnormalities,MIM# 620317

Green WARS in Intellectual disability syndromic and non-syndromic


Level 2: Neurology and neurodevelopmental disorders
Version 1.63

2 reviews BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Literature
Phenotypes
  • Neurodevelopmental disorder withmicrocephaly and speech delay, with or without brain abnormalities,MIM# 620317

Green WARS in Leukodystrophy - paediatric


Level 2: Neurology and neurodevelopmental disorders
Version 0.318

Component of the following Super Panels:

  • Leukodystrophy_Superpanel
  • Progressive Neurological Conditions

    		•  2 reviews BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Literature
    Phenotypes
    • Neurodevelopmental disorder withmicrocephaly and speech delay, with or without brain abnormalities,MIM# 620317

    Amber WARS in Hereditary Neuropathy_CMT - isolated


    Level 2: Neurology and neurodevelopmental disorders
    Version 1.51

    Component of the following Super Panels:

  • Hereditary Neuropathy_CMT_IsolatedAndComplex
  • Neuromuscular Superpanel
  • Progressive Neurological Conditions

    		•  4 reviews MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Amber
    • Literature
    • Royal Melbourne Hospital
    Phenotypes
    • Neuronopathy, distal hereditary motor, type IX, MIM#617721