PanelApp (staging)
  1. Genes and Genomic Entities
  2. TNNT1

TNNT1

troponin T1, slow skeletal type
OMIM: 191041, ClinGen, DECIPHER

9 panels

Panel Reviews Mode of inheritance Details
9 panels

Green TNNT1 in Arthrogryposis


Level 2: Neurology and neurodevelopmental disorders
Version 0.416

1 review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
Phenotypes
  • Nemaline myopathy 5, Amish type, MIM# 605355

Green TNNT1 in Mendeliome


Version 1.2302

2 reviews BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
Phenotypes
  • Nemaline myopathy 5, Amish type, MIM# 605355
  • Nemaline myopathy-5B with rigid spine and respiratory insufficiency (NEM5B), MIM#620386
  • nemaline myopathy-5C (NEM5C), autosomal dominant, MIMD620389

Green TNNT1 in Muscular dystrophy and myopathy_Paediatric


Level 2: Neurology and neurodevelopmental disorders
Version 1.85

Component of the following Super Panels:

  • Myopathy Superpanel
  • Neuromuscular Superpanel

    		•  2 reviews BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Other
    • Expert Review Green
    Phenotypes
    • Nemaline myopathy 5 MONDO:0011539
    • Nemaline myopathy MONDO:0018958

    Amber TNNT1 in Rhabdomyolysis and Metabolic Myopathy


    Level 2: Neurology and neurodevelopmental disorders
    Version 1.20

    Component of the following Super Panels:

  • Myopathy Superpanel
  • Neuromuscular Superpanel
  • Progressive Neurological Conditions

    		•  2 reviews BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Expert Review Amber
    • Expert list
    • Victorian Clinical Genetics Services
    Phenotypes
    • Nemaline myopathy 5, Amish type MIM#605355

    Green TNNT1 in Mackenzie's Mission_Reproductive Carrier Screening


    Level 2: Screening
    Version 0.109

    		0 reviews BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Mackenzie's Mission
    Phenotypes
    • Nemaline myopathy 5, Amish type, 605355 (3)

    Green TNNT1 in Additional findings_Paediatric


    Level 2: Screening
    Version 0.278

    		0 reviews BIALLELIC, autosomal or pseudoautosomal
    Sources
    • BabySeq Category A gene
    • Expert Review Green
    Phenotypes
    • Nemaline myopathy, Amish type

    Green TNNT1 in Fetal anomalies


    Version 1.313

    		1 review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Genomics England PanelApp
    • Victorian Clinical Genetics Services
    Phenotypes
    • Nemaline myopathy 5, Amish type, MIM# 605355

    Green TNNT1 in Prepair 1000+


    Level 2: Screening
    Version 1.1566

    		0 reviews BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Mackenzie's Mission
    Phenotypes
    • Nemaline myopathy 5, Amish type, 605355 (3)

    Red TNNT1 in BabyScreen+ newborn screening


    Level 2: Screening
    Version 1.116

    		2 reviews BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Red
    • BabySeq Category A gene
    Phenotypes
    • Nemaline myopathy 5, Amish type MIM#605355