PanelApp (staging)
  1. Genes and Genomic Entities
  2. SDHD

SDHD

succinate dehydrogenase complex subunit D
OMIM: 602690, ClinGen, DECIPHER

13 panels

Panel Reviews Mode of inheritance Details
13 panels

Green SDHD in Incidentalome


Version 0.318

1 review Unknown
Sources
  • Expert Review Green
  • Melbourne Genomics Health Alliance
  • Victorian Clinical Genetics Services
  • Expert Review Green

Green SDHD in Cancer Predisposition_Paediatric


Level 2: Cancer
Version 0.131

1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
Phenotypes
  • Paragangliomas 1, with or without deafness, MIM# 168000
  • Pheochromocytoma, MIM# 171300

Green SDHD in Mitochondrial disease


Level 2: Metabolic disorders
Version 0.969

Component of the following Super Panels:

  • Metabolic Disorders Superpanel
  • Progressive Neurological Conditions

    		•  1 review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services
    • Australian Genomics Health Alliance Mitochondrial Flagship
    Phenotypes
    • Mitochondrial complex II deficiency, nuclear type 3, MIM# 619167

    Green SDHD in Additional findings_Adult


    Level 2: Screening
    Version 0.169

    		1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Melbourne Genomics Health Alliance
    Phenotypes
    • Paragangliomas 1, with or without deafness, MIM# 168000
    • Pheochromocytoma, MIM# 171300

    Green SDHD in Cardiomyopathy_Paediatric


    Level 2: Cardiovascular disorders
    Version 0.196

    		0 reviews BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • MetBioNet
    • NHS GMS
    Phenotypes
    • Mitochondrial respiratory chain complex II deficiency, 252011

    Green SDHD in Additional findings_Paediatric


    Level 2: Screening
    Version 0.278

    		0 reviews MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • BabySeq Category A gene
    • Expert Review Green
    Phenotypes
    • Hereditary Paraganglioma-Pheochromocytoma Syndromes

    Red SDHD in Incidentalome_PREGEN_DRAFT


    Version 0.43

    		1 review Unknown
    Sources
    • Expert Review Red
    • NSW Health Pathology

    Red SDHD in BabyScreen+ newborn screening


    Level 2: Screening
    Version 1.116

    		2 reviews BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Expert Review Red
    • BabySeq Category A gene
    Phenotypes
    • Mitochondrial complex II deficiency, nuclear type 3, MIM# 619167
    • Paragangliomas 1, with or without deafness, MIM# 168000

    Green SDHD in Transplant Co-Morbidity Superpanel


    Level 2: Screening
    Version 0.18

    		0 reviews MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Melbourne Genomics Health Alliance
    Phenotypes
    • Pheochromocytoma, MIM# 171300
    • Paragangliomas 1, with or without deafness, MIM# 168000

    Green SDHD in Pituitary Tumour


    Level 2: Cancer Predisposition
    Version 1.1

    		1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Expert Review
    • Expert list
    Phenotypes
    • Pituitary tumor, MONDO:0017611
    • Pituitary gland adenoma, MONDO:0006373
    • Hereditary pheochromocytoma-paraganglioma, MONDO:0017366
    • Pheochromocytoma/paraganglioma syndrome 1, MIM#168000

    Green SDHD in Paraganglioma_phaeochromocytoma


    Level 2: Cancer Predisposition
    Version 1.1

    		1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Expert Review
    • Expert list
    Phenotypes
    • Paragangliomas 1, MONDO:0008192
    • Pheochromocytoma, MONDO:0008233
    • Hereditary pheochromocytoma-paraganglioma, MONDO:0017366
    • Pheochromocytoma/paraganglioma syndrome 1, MIM#168000

    Green SDHD in Kidney Cancer


    Level 2: Cancer Predisposition
    Version 1.1

    		1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Expert Review
    • Expert list
    Phenotypes
    • Renal carcinoma, MONDO:0005206
    • Hereditary pheochromocytoma-paraganglioma, MONDO:0017366
    • Pheochromocytoma/paraganglioma syndrome 1, MIM#168000

    Green SDHD in Gastrointestinal Stromal Tumour


    Level 2: Cancer Predisposition
    Version 1.0

    		1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Expert Review
    • Expert list
    Phenotypes
    • Gastrointestinal stromal tumor, MONDO:0011719
    • Hereditary pheochromocytoma-paraganglioma, MONDO:0017366
    • Pheochromocytoma/paraganglioma syndrome 1, MIM#168000