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Breast Cancer v1.1 Zornitza Stark Panel types changed to Victorian Clinical Genetics Services; Genetic Health Queensland; Cancer Germline; Adult Genetics Unit, Royal Adelaide Hospital
Breast Cancer v1.0 Zornitza Stark promoted panel to version 1.0
Breast Cancer v0.27 Zornitza Stark Panel status changed from internal to public
Breast Cancer v0.26 TP53 Zornitza Stark Marked gene: TP53 as ready
Breast Cancer v0.26 TP53 Zornitza Stark Gene: tp53 has been classified as Green List (High Evidence).
Breast Cancer v0.26 STK11 Zornitza Stark Marked gene: STK11 as ready
Breast Cancer v0.26 STK11 Zornitza Stark Gene: stk11 has been classified as Green List (High Evidence).
Breast Cancer v0.26 RAD51D Zornitza Stark Marked gene: RAD51D as ready
Breast Cancer v0.26 RAD51D Zornitza Stark Gene: rad51d has been classified as Green List (High Evidence).
Breast Cancer v0.26 RAD51C Zornitza Stark Marked gene: RAD51C as ready
Breast Cancer v0.26 RAD51C Zornitza Stark Gene: rad51c has been classified as Green List (High Evidence).
Breast Cancer v0.26 PTEN Zornitza Stark Marked gene: PTEN as ready
Breast Cancer v0.26 PTEN Zornitza Stark Gene: pten has been classified as Green List (High Evidence).
Breast Cancer v0.26 PALB2 Zornitza Stark Marked gene: PALB2 as ready
Breast Cancer v0.26 PALB2 Zornitza Stark Gene: palb2 has been classified as Green List (High Evidence).
Breast Cancer v0.26 NF1 Zornitza Stark Marked gene: NF1 as ready
Breast Cancer v0.26 NF1 Zornitza Stark Gene: nf1 has been classified as Green List (High Evidence).
Breast Cancer v0.26 CHEK2 Zornitza Stark Marked gene: CHEK2 as ready
Breast Cancer v0.26 CHEK2 Zornitza Stark Gene: chek2 has been classified as Green List (High Evidence).
Breast Cancer v0.26 CDH1 Zornitza Stark Marked gene: CDH1 as ready
Breast Cancer v0.26 CDH1 Zornitza Stark Gene: cdh1 has been classified as Green List (High Evidence).
Breast Cancer v0.26 BRCA2 Zornitza Stark Marked gene: BRCA2 as ready
Breast Cancer v0.26 BRCA2 Zornitza Stark Gene: brca2 has been classified as Green List (High Evidence).
Breast Cancer v0.26 BRCA1 Zornitza Stark Marked gene: BRCA1 as ready
Breast Cancer v0.26 BRCA1 Zornitza Stark Gene: brca1 has been classified as Green List (High Evidence).
Breast Cancer v0.26 BARD1 Zornitza Stark Marked gene: BARD1 as ready
Breast Cancer v0.26 BARD1 Zornitza Stark Gene: bard1 has been classified as Green List (High Evidence).
Breast Cancer v0.26 ATM Zornitza Stark Marked gene: ATM as ready
Breast Cancer v0.26 ATM Zornitza Stark Gene: atm has been classified as Green List (High Evidence).
Breast Cancer v0.26 CHEK2 Chirag Patel Classified gene: CHEK2 as Green List (high evidence)
Breast Cancer v0.26 CHEK2 Chirag Patel Gene: chek2 has been classified as Green List (High Evidence).
Breast Cancer v0.25 ATM Chirag Patel Classified gene: ATM as Green List (high evidence)
Breast Cancer v0.25 ATM Chirag Patel Gene: atm has been classified as Green List (High Evidence).
Breast Cancer v0.24 BARD1 Chirag Patel Classified gene: BARD1 as Green List (high evidence)
Breast Cancer v0.24 BARD1 Chirag Patel Gene: bard1 has been classified as Green List (High Evidence).
Breast Cancer v0.23 BARD1 Chirag Patel gene: BARD1 was added
gene: BARD1 was added to Breast Cancer. Sources: Expert list,Expert Review
Mode of inheritance for gene: BARD1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: BARD1 were set to Breast cancer, MONDO:0007254; BARD1-related cancer predisposition, MONDO:0700267; Breast cancer, susceptibility to, MIM#114480
Review for gene: BARD1 was set to GREEN
Added comment: ClinGen definitive. Breast cancers reported in condition.
Sources: Expert list, Expert Review
Breast Cancer v0.22 BRCA1 Chirag Patel Classified gene: BRCA1 as Green List (high evidence)
Breast Cancer v0.22 BRCA1 Chirag Patel Gene: brca1 has been classified as Green List (High Evidence).
Breast Cancer v0.21 BRCA2 Chirag Patel Classified gene: BRCA2 as Green List (high evidence)
Breast Cancer v0.21 BRCA2 Chirag Patel Gene: brca2 has been classified as Green List (High Evidence).
Breast Cancer v0.20 CDH1 Chirag Patel Classified gene: CDH1 as Green List (high evidence)
Breast Cancer v0.20 CDH1 Chirag Patel Gene: cdh1 has been classified as Green List (High Evidence).
Breast Cancer v0.19 NF1 Chirag Patel Classified gene: NF1 as Green List (high evidence)
Breast Cancer v0.19 NF1 Chirag Patel Gene: nf1 has been classified as Green List (High Evidence).
Breast Cancer v0.18 PALB2 Chirag Patel Classified gene: PALB2 as Green List (high evidence)
Breast Cancer v0.18 PALB2 Chirag Patel Gene: palb2 has been classified as Green List (High Evidence).
Breast Cancer v0.17 PTEN Chirag Patel Classified gene: PTEN as Green List (high evidence)
Breast Cancer v0.17 PTEN Chirag Patel Gene: pten has been classified as Green List (High Evidence).
Breast Cancer v0.16 RAD51C Chirag Patel Classified gene: RAD51C as Green List (high evidence)
Breast Cancer v0.16 RAD51C Chirag Patel Gene: rad51c has been classified as Green List (High Evidence).
Breast Cancer v0.15 RAD51D Chirag Patel Classified gene: RAD51D as Green List (high evidence)
Breast Cancer v0.15 RAD51D Chirag Patel Gene: rad51d has been classified as Green List (High Evidence).
Breast Cancer v0.14 STK11 Chirag Patel Classified gene: STK11 as Green List (high evidence)
Breast Cancer v0.14 STK11 Chirag Patel Gene: stk11 has been classified as Green List (High Evidence).
Breast Cancer v0.13 TP53 Chirag Patel Classified gene: TP53 as Green List (high evidence)
Breast Cancer v0.13 TP53 Chirag Patel Gene: tp53 has been classified as Green List (High Evidence).
Breast Cancer v0.12 TP53 Chirag Patel gene: TP53 was added
gene: TP53 was added to Breast Cancer. Sources: Expert list,Expert Review
Mode of inheritance for gene: TP53 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: TP53 were set to Breast cancer, MONDO:0007254; Li-Fraumeni syndrome, MONDO:0018875; Li-Fraumeni syndrome, MIM#151623
Review for gene: TP53 was set to GREEN
Added comment: ClinGen definitive. Breast cancers reported in condition.

Consider possibility that an identified variant could represent ACE (aberrant clonal expansion), which can be due to clonal haematopoiesis of indeterminate potential (CHIP) or an occult hematologic malignancy, especially in older patients who have undergone prior chemotherapy (PMID: 36040522).
Sources: Expert list, Expert Review
Breast Cancer v0.11 STK11 Chirag Patel gene: STK11 was added
gene: STK11 was added to Breast Cancer. Sources: Expert list,Expert Review
Mode of inheritance for gene: STK11 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: STK11 were set to Breast cancer, MONDO:0007254; Peutz-Jeghers syndrome, MONDO:0008280; Peutz-Jeghers syndrome, MIM#175200
Review for gene: STK11 was set to GREEN
Added comment: ClinGen definitive. Breast cancers reported in condition.

Single gene testing may be more appropriate if clinical features of JPS.
Sources: Expert list, Expert Review
Breast Cancer v0.10 RAD51D Chirag Patel gene: RAD51D was added
gene: RAD51D was added to Breast Cancer. Sources: Expert list,Expert Review
Mode of inheritance for gene: RAD51D was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: RAD51D were set to Breast cancer, MONDO:0007254; RAD51D-related cancer predisposition, MONDO:0700274; Breast-ovarian cancer, familial, susceptibility to, 4, MONDO:0013669; Breast-ovarian cancer, familial, susceptibility to, 4, MIM#614291
Review for gene: RAD51D was set to GREEN
Added comment: ClinGen definitive. Breast cancers reported in condition.
Sources: Expert list, Expert Review
Breast Cancer v0.9 RAD51C Chirag Patel gene: RAD51C was added
gene: RAD51C was added to Breast Cancer. Sources: Expert list,Expert Review
Mode of inheritance for gene: RAD51C was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: RAD51C were set to Breast cancer, MONDO:0007254; RAD51C-related cancer predisposition, MONDO:0700273; Breast-ovarian cancer, familial, susceptibility to, 3, MONDO:0013253; Breast-ovarian cancer, familial, susceptibility to, 3, MIM#613399
Review for gene: RAD51C was set to GREEN
Added comment: ClinGen definitive. Breast cancers reported in condition.
Sources: Expert list, Expert Review
Breast Cancer v0.8 PTEN Chirag Patel gene: PTEN was added
gene: PTEN was added to Breast Cancer. Sources: Expert list,Expert Review
Mode of inheritance for gene: PTEN was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: PTEN were set to Breast cancer, MONDO:0007254; PTEN hamartoma tumor syndrome, MONDO:0017623; PTEN hamartoma tumour syndromes, MIM#158350
Review for gene: PTEN was set to GREEN
Added comment: ClinGen definitive. Breast cancers reported in condition.
Sources: Expert list, Expert Review
Breast Cancer v0.7 PALB2 Chirag Patel gene: PALB2 was added
gene: PALB2 was added to Breast Cancer. Sources: Expert list,Expert Review
Mode of inheritance for gene: PALB2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: PALB2 were set to Breast cancer, MONDO:0007254; PALB2-related cancer predisposition, MONDO:0700272; Breast-ovarian cancer, familial, susceptibility to, 5, MIM#620442; Pancreatic cancer, susceptibility to, 3, MIM#613348
Review for gene: PALB2 was set to GREEN
Added comment: ClinGen definitive. Breast cancers reported in condition.
Sources: Expert list, Expert Review
Breast Cancer v0.6 NF1 Chirag Patel gene: NF1 was added
gene: NF1 was added to Breast Cancer. Sources: Expert list,Expert Review
Mode of inheritance for gene: NF1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: NF1 were set to Breast cancer, MONDO:0007254; Neurofibromatosis type 1, MONDO:0018975; Neurofibromatosis, type 1, MIM#162200
Review for gene: NF1 was set to GREEN
Added comment: ClinGen definitive. Breast cancers reported in condition.

Single gene testing may be more appropriate if clinical features of NF1.
Sources: Expert list, Expert Review
Breast Cancer v0.5 CDH1 Chirag Patel gene: CDH1 was added
gene: CDH1 was added to Breast Cancer. Sources: Expert list,Expert Review
Mode of inheritance for gene: CDH1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: CDH1 were set to Breast cancer, MONDO:0007254; CDH1-related diffuse gastric and lobular breast cancer syndrome, MONDO:0100488; Diffuse gastric and lobular breast cancer syndrome with or without cleft lip and/or palate, MIM#137215
Review for gene: CDH1 was set to GREEN
Added comment: ClinGen definitive. Breast cancers reported in condition.
Sources: Expert list, Expert Review
Breast Cancer v0.4 BRCA2 Chirag Patel gene: BRCA2 was added
gene: BRCA2 was added to Breast Cancer. Sources: Expert list,Expert Review
Mode of inheritance for gene: BRCA2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: BRCA2 were set to Breast cancer, MONDO:0007254; BRCA2-related cancer predisposition, MONDO:0700269; Breast-ovarian cancer, familial, 2, MIM#612555
Review for gene: BRCA2 was set to GREEN
Added comment: ClinGen definitive. Breast cancers reported in condition.
Sources: Expert list, Expert Review
Breast Cancer v0.3 BRCA1 Chirag Patel gene: BRCA1 was added
gene: BRCA1 was added to Breast Cancer. Sources: Expert list,Expert Review
Mode of inheritance for gene: BRCA1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: BRCA1 were set to Breast cancer, MONDO:0007254; BRCA1-related cancer predisposition, MONDO:0700268; Breast-ovarian cancer, familial, 1, MIM#604370
Review for gene: BRCA1 was set to GREEN
Added comment: ClinGen definitive. Breast cancers reported in condition.
Sources: Expert list, Expert Review
Breast Cancer v0.2 ATM Chirag Patel gene: ATM was added
gene: ATM was added to Breast Cancer. Sources: Expert list,Expert Review
Mode of inheritance for gene: ATM was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: ATM were set to Breast cancer, MONDO:0007254; ATM-related cancer predisposition, MONDO:0700270; Breast cancer, susceptibility to, MIM#114480
Review for gene: ATM was set to GREEN
Added comment: ClinGen definitive. Breast cancers reported in condition.

Consider possibility that an identified variant could represent ACE (aberrant clonal expansion), which can be due to clonal haematopoiesis of indeterminate potential (CHIP) or an occult hematologic malignancy, especially in older patients who have undergone prior chemotherapy (PMID: 36040522).
Sources: Expert list, Expert Review
Breast Cancer v0.1 CHEK2 Chirag Patel gene: CHEK2 was added
gene: CHEK2 was added to Breast Cancer. Sources: Expert list,Expert Review,Literature
Mode of inheritance for gene: CHEK2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications for gene: CHEK2 were set to PMID: 33322746, 36529447
Phenotypes for gene: CHEK2 were set to Breast cancer, MONDO:0007254; CHEK2-related cancer predisposition, MONDO:0700271; Breast/prostate cancer, susceptibility to, MIM#609265
Review for gene: CHEK2 was set to GREEN
Added comment: Established gene-disease association. Breast cancers reported in condition.

Consider possibility that an identified variant could represent ACE (aberrant clonal expansion), which can be due to clonal haematopoiesis of indeterminate potential (CHIP) or an occult hematologic malignancy, especially in older patients who have undergone prior chemotherapy (PMID: 36040522).
Sources: Expert list, Expert Review, Literature
Breast Cancer v0.0 Chirag Patel Added Panel Breast Cancer
Set panel types to: Cancer Germline