| Date | Panel | Item | Activity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Pancreatic Cancer v1.1 | Zornitza Stark Panel types changed to Victorian Clinical Genetics Services; Genetic Health Queensland; Cancer Germline; Adult Genetics Unit, Royal Adelaide Hospital | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v1.0 | Zornitza Stark promoted panel to version 1.0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.25 | Zornitza Stark Panel status changed from internal to public | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | TP53 | Zornitza Stark Marked gene: TP53 as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | TP53 | Zornitza Stark Gene: tp53 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | STK11 | Zornitza Stark Marked gene: STK11 as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | STK11 | Zornitza Stark Gene: stk11 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | PMS2 | Zornitza Stark Marked gene: PMS2 as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | PMS2 | Zornitza Stark Gene: pms2 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | PALB2 | Zornitza Stark Marked gene: PALB2 as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | PALB2 | Zornitza Stark Gene: palb2 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | MSH6 | Zornitza Stark Marked gene: MSH6 as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | MSH6 | Zornitza Stark Gene: msh6 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | MSH2 | Zornitza Stark Marked gene: MSH2 as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | MSH2 | Zornitza Stark Gene: msh2 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | MLH1 | Zornitza Stark Marked gene: MLH1 as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | MLH1 | Zornitza Stark Gene: mlh1 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | EPCAM | Zornitza Stark Marked gene: EPCAM as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | EPCAM | Zornitza Stark Gene: epcam has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | CDKN2A | Zornitza Stark Marked gene: CDKN2A as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | CDKN2A | Zornitza Stark Gene: cdkn2a has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | BRCA2 | Zornitza Stark Marked gene: BRCA2 as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | BRCA2 | Zornitza Stark Gene: brca2 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | BRCA1 | Zornitza Stark Marked gene: BRCA1 as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | BRCA1 | Zornitza Stark Gene: brca1 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | ATM | Zornitza Stark Marked gene: ATM as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | ATM | Zornitza Stark Gene: atm has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | ATM |
Chirag Patel changed review comment from: ClinGen definitive. Pancreatic cancer reported in condition. Sources: Expert list, Expert Review; to: ClinGen definitive. Pancreatic cancer reported in condition. Consider possibility that an identified variant could represent ACE (aberrant clonal expansion), which can be due to clonal haematopoiesis of indeterminate potential (CHIP) or an occult hematologic malignancy, especially in older patients who have undergone prior chemotherapy (PMID: 36040522). Sources: Expert list, Expert Review |
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| Pancreatic Cancer v0.24 | TP53 |
Chirag Patel changed review comment from: ClinGen definitive. Pancreatic cancer reported in condition. Consider possibility that an identified variant could represent ACE (aberrant clonal expansion), which can be due to clonal haematopoiesis of indeterminate potential (CHIP) or an occult hematologic malignancy, especially in older patients who have undergone prior chemotherapy. Genes most commonly associated with ACE include ATM, CHEK2, and TP53 (PMID: 36040522). Sources: Expert list, Expert Review; to: ClinGen definitive. Pancreatic cancer reported in condition. Consider possibility that an identified variant could represent ACE (aberrant clonal expansion), which can be due to clonal haematopoiesis of indeterminate potential (CHIP) or an occult hematologic malignancy, especially in older patients who have undergone prior chemotherapy (PMID: 36040522). Sources: Expert list, Expert Review |
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| Pancreatic Cancer v0.24 | TP53 |
Chirag Patel changed review comment from: ClinGen definitive. Pancreatic cancer reported in condition. Sources: Expert list, Expert Review; to: ClinGen definitive. Pancreatic cancer reported in condition. Consider possibility that an identified variant could represent ACE (aberrant clonal expansion), which can be due to clonal haematopoiesis of indeterminate potential (CHIP) or an occult hematologic malignancy, especially in older patients who have undergone prior chemotherapy. Genes most commonly associated with ACE include ATM, CHEK2, and TP53 (PMID: 36040522). Sources: Expert list, Expert Review |
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| Pancreatic Cancer v0.24 | ATM | Chirag Patel Classified gene: ATM as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | ATM | Chirag Patel Gene: atm has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.23 | STK11 | Chirag Patel Classified gene: STK11 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.23 | STK11 | Chirag Patel Gene: stk11 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.22 | TP53 | Chirag Patel Classified gene: TP53 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.22 | TP53 | Chirag Patel Gene: tp53 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.21 | PALB2 | Chirag Patel Classified gene: PALB2 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.21 | PALB2 | Chirag Patel Gene: palb2 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.20 | BRCA1 | Chirag Patel Classified gene: BRCA1 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.20 | BRCA1 | Chirag Patel Gene: brca1 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.19 | BRCA2 | Chirag Patel Classified gene: BRCA2 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.19 | BRCA2 | Chirag Patel Gene: brca2 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.18 | CDKN2A | Chirag Patel Classified gene: CDKN2A as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.18 | CDKN2A | Chirag Patel Gene: cdkn2a has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.17 | CDKN2A |
Chirag Patel gene: CDKN2A was added gene: CDKN2A was added to Pancreatic Cancer. Sources: Expert list,Expert Review Mode of inheritance for gene: CDKN2A was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: CDKN2A were set to Malignant pancreatic neoplasm, MONDO:0009831; Melanoma-pancreatic cancer syndrome, MONDO:0011713; Melanoma and neural system tumor syndrome, MONDO:0007967; Melanoma cutaneous malignant susceptibility to 2, MONDO:0007964; Melanoma, cutaneous malignant, 2, MIM#155601; Melanoma-pancreatic cancer syndrome, MIM#606719; Melanoma and neural system tumor syndrome, MIM#155755 Review for gene: CDKN2A was set to GREEN Added comment: ClinGen definitive. Pancreatic cancer reported in condition Sources: Expert list, Expert Review |
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| Pancreatic Cancer v0.16 | BRCA1 |
Chirag Patel gene: BRCA1 was added gene: BRCA1 was added to Pancreatic Cancer. Sources: Expert list,Expert Review Mode of inheritance for gene: BRCA1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: BRCA1 were set to Malignant pancreatic neoplasm, MONDO:0009831; BRCA1-related cancer predisposition, MONDO:0700268; Breast-ovarian cancer, familial, 1, MIM#604370 Review for gene: BRCA1 was set to GREEN Added comment: ClinGen definitive. Pancreatic cancer reported in condition. Sources: Expert list, Expert Review |
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| Pancreatic Cancer v0.15 | BRCA2 |
Chirag Patel gene: BRCA2 was added gene: BRCA2 was added to Pancreatic Cancer. Sources: Expert list,Expert Review Mode of inheritance for gene: BRCA2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: BRCA2 were set to Malignant pancreatic neoplasm, MONDO:0009831; BRCA2-related cancer predisposition, MONDO:0700269; Breast-ovarian cancer, familial, 2, MIM#612555 Review for gene: BRCA2 was set to GREEN Added comment: ClinGen definitive. Pancreatic cancer reported in condition. Sources: Expert list, Expert Review |
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| Pancreatic Cancer v0.14 | PALB2 |
Chirag Patel gene: PALB2 was added gene: PALB2 was added to Pancreatic Cancer. Sources: Expert list,Expert Review Mode of inheritance for gene: PALB2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: PALB2 were set to Malignant pancreatic neoplasm, MONDO:0009831; PALB2-related cancer predisposition, MONDO:0700272; Breast-ovarian cancer, familial, susceptibility to, 5, MIM#620442; Pancreatic cancer, susceptibility to, 3, MIM#613348 Review for gene: PALB2 was set to GREEN Added comment: ClinGen definitive. Pancreatic cancer reported in condition. Sources: Expert list, Expert Review |
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| Pancreatic Cancer v0.13 | TP53 |
Chirag Patel gene: TP53 was added gene: TP53 was added to Pancreatic Cancer. Sources: Expert list,Expert Review Mode of inheritance for gene: TP53 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: TP53 were set to Malignant pancreatic neoplasm, MONDO:0009831; Li-Fraumeni syndrome, MONDO:0018875; Li-Fraumeni syndrome, MIM#151623 Review for gene: TP53 was set to GREEN Added comment: ClinGen definitive. Pancreatic cancer reported in condition. Sources: Expert list, Expert Review |
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| Pancreatic Cancer v0.12 | STK11 |
Chirag Patel gene: STK11 was added gene: STK11 was added to Pancreatic Cancer. Sources: Expert list,Expert Review Mode of inheritance for gene: STK11 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: STK11 were set to Malignant pancreatic neoplasm, MONDO:0009831; Peutz-Jeghers syndrome, MONDO:0008280; Peutz-Jeghers syndrome, MIM#175200 Review for gene: STK11 was set to GREEN Added comment: ClinGen definitive. Pancreatic cancer reported in condition. Single gene testing may be more appropriate if clinical features of JPS. Sources: Expert list, Expert Review |
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| Pancreatic Cancer v0.11 | ATM |
Chirag Patel gene: ATM was added gene: ATM was added to Pancreatic Cancer. Sources: Expert list,Expert Review Mode of inheritance for gene: ATM was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: ATM were set to Malignant pancreatic neoplasm, MONDO:0009831; ATM-related cancer predisposition, MONDO:0700270; Breast cancer, susceptibility to, MIM#114480 Review for gene: ATM was set to GREEN Added comment: ClinGen definitive. Pancreatic cancer reported in condition. Sources: Expert list, Expert Review |
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| Pancreatic Cancer v0.10 | EPCAM | Chirag Patel Classified gene: EPCAM as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.10 | EPCAM | Chirag Patel Gene: epcam has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.9 | PMS2 | Chirag Patel Classified gene: PMS2 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.9 | PMS2 | Chirag Patel Gene: pms2 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.8 | MSH6 | Chirag Patel Classified gene: MSH6 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.8 | MSH6 | Chirag Patel Gene: msh6 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.7 | MSH2 | Chirag Patel Classified gene: MSH2 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.7 | MSH2 | Chirag Patel Gene: msh2 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.6 | MLH1 | Chirag Patel Classified gene: MLH1 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.6 | MLH1 | Chirag Patel Gene: mlh1 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.5 | PMS2 |
Chirag Patel gene: PMS2 was added gene: PMS2 was added to Pancreatic Cancer. Sources: Expert list,Expert Review Mode of inheritance for gene: PMS2 was set to BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal Phenotypes for gene: PMS2 were set to Malignant pancreatic neoplasm, MONDO:0009831; Lynch syndrome 4, MONDO:0013699; Mismatch repair cancer syndrome 4, MONDO:0030843; Lynch syndrome 4, MIM#614337; Mismatch repair cancer syndrome 4, MIM#619101 Review for gene: PMS2 was set to GREEN Added comment: ClinGen definitive. Pancreatic cancer reported in condition. Note: there is a high level of homology between PMS2 and pseudogenes. Sources: Expert list, Expert Review |
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| Pancreatic Cancer v0.4 | MSH6 |
Chirag Patel gene: MSH6 was added gene: MSH6 was added to Pancreatic Cancer. Sources: Expert list,Expert Review Mode of inheritance for gene: MSH6 was set to BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal Phenotypes for gene: MSH6 were set to Malignant pancreatic neoplasm, MONDO:0009831; Lynch syndrome 5, MONDO:0013710; Mismatch repair cancer syndrome 3, MONDO:0030841; Lynch syndrome 5, MIM#614350; Mismatch repair cancer syndrome 3, MIM#619097 Review for gene: MSH6 was set to GREEN Added comment: ClinGen definitive. Pancreatic cancer reported in condition. Sources: Expert list, Expert Review |
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| Pancreatic Cancer v0.3 | MSH2 |
Chirag Patel gene: MSH2 was added gene: MSH2 was added to Pancreatic Cancer. Sources: Expert list,Expert Review Mode of inheritance for gene: MSH2 was set to BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal Phenotypes for gene: MSH2 were set to Malignant pancreatic neoplasm, MONDO:0009831; Lynch syndrome 1, MONDO:0007356; Mismatch repair cancer syndrome 2, MONDO:0030840; Lynch syndrome 1, MIM#120435; Mismatch repair cancer syndrome 2, MIM#619096 Review for gene: MSH2 was set to GREEN Added comment: ClinGen definitive. Pancreatic cancer reported in condition. Sources: Expert list, Expert Review |
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| Pancreatic Cancer v0.2 | MLH1 |
Chirag Patel gene: MLH1 was added gene: MLH1 was added to Pancreatic Cancer. Sources: Expert list,Expert Review Mode of inheritance for gene: MLH1 was set to BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal Phenotypes for gene: MLH1 were set to Malignant pancreatic neoplasm, MONDO:0009831; Lynch syndrome 2, MONDO:0012249; Mismatch repair cancer syndrome 1, MONDO:0010159; Lynch syndrome 2, MIM#609310; Mismatch repair cancer syndrome 1, MIM#276300 Review for gene: MLH1 was set to GREEN Added comment: ClinGen definitive. Pancreatic cancer reported in condition. Sources: Expert list, Expert Review |
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| Pancreatic Cancer v0.1 | EPCAM |
Chirag Patel gene: EPCAM was added gene: EPCAM was added to Pancreatic Cancer. Sources: Expert list,Expert Review Mode of inheritance for gene: EPCAM was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: EPCAM were set to Malignant pancreatic neoplasm, MONDO:0009831; Lynch syndrome 8, MONDO:0013196; Lynch syndrome 8, MIM#613244 Review for gene: EPCAM was set to GREEN Added comment: ClinGen definitive. Pancreatic cancer reported in condition. Deletion of 3’end of EPCAM gene leading to epigenetic silencing of adjacent downstream MSH2 gene. Sources: Expert list, Expert Review |
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| Pancreatic Cancer v0.0 |
Chirag Patel Added Panel Pancreatic Cancer Set panel types to: Cancer Germline |
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