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Lymphoedema_nonsyndromic v0.44 MDFIC Zornitza Stark Marked gene: MDFIC as ready
Lymphoedema_nonsyndromic v0.44 MDFIC Zornitza Stark Gene: mdfic has been classified as Green List (High Evidence).
Lymphoedema_nonsyndromic v0.44 MDFIC Zornitza Stark Classified gene: MDFIC as Green List (high evidence)
Lymphoedema_nonsyndromic v0.44 MDFIC Zornitza Stark Gene: mdfic has been classified as Green List (High Evidence).
Lymphoedema_nonsyndromic v0.43 MDFIC Zornitza Stark Classified gene: MDFIC as Green List (high evidence)
Lymphoedema_nonsyndromic v0.43 MDFIC Zornitza Stark Gene: mdfic has been classified as Green List (High Evidence).
Lymphoedema_nonsyndromic v0.40 MDFIC Krithika Murali gene: MDFIC was added
gene: MDFIC was added to Lymphoedema_nonsyndromic. Sources: Literature
Mode of inheritance for gene: MDFIC was set to BIALLELIC, autosomal or pseudoautosomal
Publications for gene: MDFIC were set to PMID: 35235341
Phenotypes for gene: MDFIC were set to Lymphatic malformation 12 - MIM#620014
Review for gene: MDFIC was set to GREEN
Added comment: Biallelic LoF variants associated with central conducting lymphatic anomaly.
Sources: Literature
Lymphoedema_nonsyndromic v0.40 MDFIC Krithika Murali gene: MDFIC was added
gene: MDFIC was added to Lymphoedema_nonsyndromic. Sources: Literature
Mode of inheritance for gene: MDFIC was set to BIALLELIC, autosomal or pseudoautosomal
Publications for gene: MDFIC were set to PMID: 35235341
Phenotypes for gene: MDFIC were set to Lymphatic malformation 12 - MIM#620014
Review for gene: MDFIC was set to GREEN
Added comment: Biallelic LoF variants associated with central conducting lymphatic anomaly.
Sources: Literature
Lymphoedema_nonsyndromic v0.39 HGF Zornitza Stark Marked gene: HGF as ready
Lymphoedema_nonsyndromic v0.39 HGF Zornitza Stark Gene: hgf has been classified as Green List (High Evidence).
Lymphoedema_nonsyndromic v0.39 HGF Zornitza Stark Classified gene: HGF as Green List (high evidence)
Lymphoedema_nonsyndromic v0.39 HGF Zornitza Stark Gene: hgf has been classified as Green List (High Evidence).
Lymphoedema_nonsyndromic v0.38 HGF Zornitza Stark gene: HGF was added
gene: HGF was added to Lymphoedema_nonsyndromic. Sources: Literature
Mode of inheritance for gene: HGF was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications for gene: HGF were set to 38676400; 38791500
Phenotypes for gene: HGF were set to Lymphoedema, MONDO:0019297, HGF-related
Review for gene: HGF was set to GREEN
Added comment: More than 10 families reported with childhood- to late-onset lymphoedema.
Sources: Literature
Lymphoedema_nonsyndromic v0.37 TIE1 Ain Roesley Publications for gene: TIE1 were set to 32947856; 24764452; 38820174
Lymphoedema_nonsyndromic v0.36 TIE1 Ain Roesley Publications for gene: TIE1 were set to 32947856; 24764452; 38820174
Lymphoedema_nonsyndromic v0.36 TIE1 Ain Roesley Publications for gene: TIE1 were set to 32947856; 24764452
Lymphoedema_nonsyndromic v0.36 TIE1 Ain Roesley Classified gene: TIE1 as Green List (high evidence)
Lymphoedema_nonsyndromic v0.36 TIE1 Ain Roesley Gene: tie1 has been classified as Green List (High Evidence).
Lymphoedema_nonsyndromic v0.35 TIE1 Ain Roesley edited their review of gene: TIE1: Changed rating: GREEN; Changed mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Lymphoedema_nonsyndromic v0.35 TIE1 Ain Roesley reviewed gene: TIE1: Rating: ; Mode of pathogenicity: None; Publications: 38820174; Phenotypes: Lymphatic malformation 11, MIM# 619401; Mode of inheritance: None; Current diagnostic: yes
Lymphoedema_nonsyndromic v0.35 ERG Zornitza Stark Phenotypes for gene: ERG were changed from primary lymphoedema MONDO#0019175, ERG-related to Lymphatic malformation 14, MIM# 620602
Lymphoedema_nonsyndromic v0.34 ERG Zornitza Stark reviewed gene: ERG: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: Lymphatic malformation 14, MIM# 620602; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Lymphoedema_nonsyndromic v0.34 ARAP3 Zornitza Stark Phenotypes for gene: ARAP3 were changed from Lymphoedema to Lymphoedema, MONDO:0019297, ARAP3-related
Lymphoedema_nonsyndromic v0.33 ARAP3 Zornitza Stark edited their review of gene: ARAP3: Changed phenotypes: Lymphoedema, MONDO:0019297, ARAP3-related
Lymphoedema_nonsyndromic v0.33 ERG Ain Roesley Classified gene: ERG as Green List (high evidence)
Lymphoedema_nonsyndromic v0.33 ERG Ain Roesley Gene: erg has been classified as Green List (High Evidence).
Lymphoedema_nonsyndromic v0.33 ERG Ain Roesley Classified gene: ERG as Green List (high evidence)
Lymphoedema_nonsyndromic v0.33 ERG Ain Roesley Gene: erg has been classified as Green List (High Evidence).
Lymphoedema_nonsyndromic v0.33 ERG Ain Roesley Classified gene: ERG as Green List (high evidence)
Lymphoedema_nonsyndromic v0.33 ERG Ain Roesley Gene: erg has been classified as Green List (High Evidence).
Lymphoedema_nonsyndromic v0.33 ERG Ain Roesley Classified gene: ERG as Green List (high evidence)
Lymphoedema_nonsyndromic v0.33 ERG Ain Roesley Gene: erg has been classified as Green List (High Evidence).
Lymphoedema_nonsyndromic v0.33 ERG Ain Roesley Classified gene: ERG as Green List (high evidence)
Lymphoedema_nonsyndromic v0.33 ERG Ain Roesley Gene: erg has been classified as Green List (High Evidence).
Lymphoedema_nonsyndromic v0.32 ERG Ain Roesley Marked gene: ERG as ready
Lymphoedema_nonsyndromic v0.32 ERG Ain Roesley Gene: erg has been classified as Red List (Low Evidence).
Lymphoedema_nonsyndromic v0.32 ERG Ain Roesley gene: ERG was added
gene: ERG was added to Lymphoedema_nonsyndromic. Sources: Literature
Mode of inheritance for gene: ERG was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications for gene: ERG were set to 36928819
Phenotypes for gene: ERG were set to primary lymphoedema MONDO#0019175, ERG-related
Penetrance for gene: ERG were set to unknown
Review for gene: ERG was set to GREEN
gene: ERG was marked as current diagnostic
Added comment: 3 families with fs variants
2x NMD = 1x de novo + 1x mosaic father
1x protein truncating = 2 affected siblings with an unaffected father who wasn't sequenced

4th family with protein truncating variant but has other clinical features and lymphoedema was only identified upon chart review

over expression of mutant cDNA demonstrated mislocalisation into the cytoplasm
Sources: Literature
Lymphoedema_nonsyndromic v0.31 Zornitza Stark Panel types changed to Victorian Clinical Genetics Services; Rare Disease
Lymphoedema_nonsyndromic v0.30 Zornitza Stark HPO terms changed from to Lymphedema, HP:0001004
List of related panels changed from to Lymphedema; HP:0001004
Lymphoedema_nonsyndromic v0.29 ANGPT2 Zornitza Stark Phenotypes for gene: ANGPT2 were changed from Lymphatic malformation-10, MIM#619369; Primary lymphoedema to Lymphatic malformation-10, MIM#619369; Primary lymphoedema; Hydrops
Lymphoedema_nonsyndromic v0.28 ANGPT2 Zornitza Stark Publications for gene: ANGPT2 were set to 32908006
Lymphoedema_nonsyndromic v0.27 ANGPT2 Zornitza Stark Mode of inheritance for gene: ANGPT2 was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Lymphoedema_nonsyndromic v0.26 ANGPT2 Zornitza Stark edited their review of gene: ANGPT2: Added comment: Bi-allelic disease PMID 34876502: single family reported with four fetuses with hydrops fetalis homozygous for ANGPT2 NM_001147.2:c.557A>G. The consanguineous parents and surviving sibblings (a girl and a boy), were heterozygous for this variant. This variant is predicted to create a cryptic exonic splice site, resulting in a r.557_566del and nonsense-mediated mRNA decay. This prediction was supported by the lack of a transcript from this allele in the parents.; Changed publications: 32908006, 34876502; Changed phenotypes: Lymphatic malformation-10, MIM#619369, Primary lymphoedema, Hydrops; Changed mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Lymphoedema_nonsyndromic v0.26 TIE1 Zornitza Stark Marked gene: TIE1 as ready
Lymphoedema_nonsyndromic v0.26 TIE1 Zornitza Stark Gene: tie1 has been classified as Amber List (Moderate Evidence).
Lymphoedema_nonsyndromic v0.26 TIE1 Zornitza Stark Classified gene: TIE1 as Amber List (moderate evidence)
Lymphoedema_nonsyndromic v0.26 TIE1 Zornitza Stark Gene: tie1 has been classified as Amber List (Moderate Evidence).
Lymphoedema_nonsyndromic v0.25 TIE1 Zornitza Stark gene: TIE1 was added
gene: TIE1 was added to Lymphoedema_nonsyndromic. Sources: Literature
Mode of inheritance for gene: TIE1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications for gene: TIE1 were set to 32947856; 24764452
Phenotypes for gene: TIE1 were set to Lymphatic malformation 11, MIM# 619401
Review for gene: TIE1 was set to AMBER
Added comment: Three families reported, supportive animal model, though variants are missense and present at a low frequency in gnomad.
Sources: Literature
Lymphoedema_nonsyndromic v0.24 ANGPT2 Zornitza Stark Phenotypes for gene: ANGPT2 were changed from Primary lymphoedema to Lymphatic malformation-10, MIM#619369; Primary lymphoedema
Lymphoedema_nonsyndromic v0.23 ANGPT2 Zornitza Stark edited their review of gene: ANGPT2: Changed phenotypes: Lymphatic malformation-10, MIM#619369, Primary lymphoedema
Lymphoedema_nonsyndromic v0.23 CELSR1 Zornitza Stark Publications for gene: CELSR1 were set to 31215153
Lymphoedema_nonsyndromic v0.22 CELSR1 Zornitza Stark commented on gene: CELSR1: 3 unrelated families reported.
Lymphoedema_nonsyndromic v0.22 CELSR1 Zornitza Stark edited their review of gene: CELSR1: Changed publications: 31215153, 31403174, 26855770
Lymphoedema_nonsyndromic v0.22 CELSR1 Zornitza Stark Phenotypes for gene: CELSR1 were changed from lymphoedema to Lymphatic malformation 9, MIM# 619319
Lymphoedema_nonsyndromic v0.21 CELSR1 Zornitza Stark reviewed gene: CELSR1: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: Lymphatic malformation 9, MIM# 619319; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Lymphoedema_nonsyndromic v0.21 ARAP3 Zornitza Stark Marked gene: ARAP3 as ready
Lymphoedema_nonsyndromic v0.21 ARAP3 Zornitza Stark Gene: arap3 has been classified as Amber List (Moderate Evidence).
Lymphoedema_nonsyndromic v0.21 ARAP3 Zornitza Stark Classified gene: ARAP3 as Amber List (moderate evidence)
Lymphoedema_nonsyndromic v0.21 ARAP3 Zornitza Stark Gene: arap3 has been classified as Amber List (Moderate Evidence).
Lymphoedema_nonsyndromic v0.20 ARAP3 Zornitza Stark gene: ARAP3 was added
gene: ARAP3 was added to Lymphoedema_nonsyndromic. Sources: Literature
Mode of inheritance for gene: ARAP3 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications for gene: ARAP3 were set to 32908855
Phenotypes for gene: ARAP3 were set to Lymphoedema
Review for gene: ARAP3 was set to AMBER
Added comment: Three unrelated families reported with rare missense variants in this gene as part of a lymphoedema cohort. However, incomplete information regarding segregation and no supporting functional data.
Sources: Literature
Lymphoedema_nonsyndromic v0.19 RORC Zornitza Stark Marked gene: RORC as ready
Lymphoedema_nonsyndromic v0.19 RORC Zornitza Stark Gene: rorc has been classified as Amber List (Moderate Evidence).
Lymphoedema_nonsyndromic v0.19 RORC Zornitza Stark Classified gene: RORC as Amber List (moderate evidence)
Lymphoedema_nonsyndromic v0.19 RORC Zornitza Stark Gene: rorc has been classified as Amber List (Moderate Evidence).
Lymphoedema_nonsyndromic v0.18 RORC Zornitza Stark gene: RORC was added
gene: RORC was added to Lymphoedema_nonsyndromic. Sources: Literature
Mode of inheritance for gene: RORC was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications for gene: RORC were set to 32960152
Phenotypes for gene: RORC were set to Lymphoedema
Review for gene: RORC was set to AMBER
Added comment: Two individuals reported with LoF variants as part of a large cohort. Note gene is depleted for LoF in gnomad, and bi-allelic variants have been associated with immunodeficiency.
Sources: Literature
Lymphoedema_nonsyndromic v0.17 KIF11 Zornitza Stark Marked gene: KIF11 as ready
Lymphoedema_nonsyndromic v0.17 KIF11 Zornitza Stark Gene: kif11 has been classified as Amber List (Moderate Evidence).
Lymphoedema_nonsyndromic v0.17 KIF11 Zornitza Stark Phenotypes for gene: KIF11 were changed from to Microcephaly with or without chorioretinopathy, lymphoedema, or mental retardation, MIM# 152950; MONDO:0007918
Lymphoedema_nonsyndromic v0.16 KIF11 Zornitza Stark Publications for gene: KIF11 were set to
Lymphoedema_nonsyndromic v0.15 KIF11 Zornitza Stark Mode of inheritance for gene: KIF11 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Lymphoedema_nonsyndromic v0.14 KIF11 Zornitza Stark Classified gene: KIF11 as Amber List (moderate evidence)
Lymphoedema_nonsyndromic v0.14 KIF11 Zornitza Stark Gene: kif11 has been classified as Amber List (Moderate Evidence).
Lymphoedema_nonsyndromic v0.13 KIF11 Zornitza Stark reviewed gene: KIF11: Rating: AMBER; Mode of pathogenicity: None; Publications: 22284827, 25115524, 25124931, 27212378, 32730767, 31993640, 25996076; Phenotypes: Microcephaly with or without chorioretinopathy, lymphoedema, or mental retardation, MIM# 152950, MONDO:0007918; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Lymphoedema_nonsyndromic v0.13 VEGFC Zornitza Stark Marked gene: VEGFC as ready
Lymphoedema_nonsyndromic v0.13 VEGFC Zornitza Stark Gene: vegfc has been classified as Green List (High Evidence).
Lymphoedema_nonsyndromic v0.13 VEGFC Zornitza Stark Phenotypes for gene: VEGFC were changed from to Lymphatic malformation 4, MIM#615907
Lymphoedema_nonsyndromic v0.12 VEGFC Zornitza Stark Publications for gene: VEGFC were set to
Lymphoedema_nonsyndromic v0.11 VEGFC Zornitza Stark Mode of inheritance for gene: VEGFC was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Lymphoedema_nonsyndromic v0.10 VEGFC Zornitza Stark reviewed gene: VEGFC: Rating: GREEN; Mode of pathogenicity: None; Publications: 23410910, 24744435, 30071673; Phenotypes: Lymphatic malformation 4, MIM#615907; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Lymphoedema_nonsyndromic v0.10 ANGPT2 Zornitza Stark Publications for gene: ANGPT2 were set to https://stm.sciencemag.org/content/12/560/eaax8013
Lymphoedema_nonsyndromic v0.9 ANGPT2 Zornitza Stark edited their review of gene: ANGPT2: Changed publications: 32908006
Lymphoedema_nonsyndromic v0.9 ANGPT2 Zornitza Stark Marked gene: ANGPT2 as ready
Lymphoedema_nonsyndromic v0.9 ANGPT2 Zornitza Stark Gene: angpt2 has been classified as Green List (High Evidence).
Lymphoedema_nonsyndromic v0.9 ANGPT2 Zornitza Stark Classified gene: ANGPT2 as Green List (high evidence)
Lymphoedema_nonsyndromic v0.9 ANGPT2 Zornitza Stark Gene: angpt2 has been classified as Green List (High Evidence).
Lymphoedema_nonsyndromic v0.8 ANGPT2 Zornitza Stark gene: ANGPT2 was added
gene: ANGPT2 was added to Lymphoedema_nonsyndromic. Sources: Literature
Mode of inheritance for gene: ANGPT2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications for gene: ANGPT2 were set to https://stm.sciencemag.org/content/12/560/eaax8013
Phenotypes for gene: ANGPT2 were set to Primary lymphoedema
Review for gene: ANGPT2 was set to GREEN
Added comment: Five unrelated individuals reported with primary lymphedema and variants in this gene, together with functional data.
Sources: Literature
Lymphoedema_nonsyndromic v0.7 ADAMTS3 Zornitza Stark Marked gene: ADAMTS3 as ready
Lymphoedema_nonsyndromic v0.7 ADAMTS3 Zornitza Stark Gene: adamts3 has been classified as Green List (High Evidence).
Lymphoedema_nonsyndromic v0.7 ADAMTS3 Zornitza Stark Classified gene: ADAMTS3 as Green List (high evidence)
Lymphoedema_nonsyndromic v0.7 ADAMTS3 Zornitza Stark Gene: adamts3 has been classified as Green List (High Evidence).
Lymphoedema_nonsyndromic v0.6 ADAMTS3 Chris Richmond gene: ADAMTS3 was added
gene: ADAMTS3 was added to Lymphoedema_nonsyndromic. Sources: Expert Review
Mode of inheritance for gene: ADAMTS3 was set to BIALLELIC, autosomal or pseudoautosomal
Publications for gene: ADAMTS3 were set to 28985353, 30450763
Phenotypes for gene: ADAMTS3 were set to Hennekam lymphangiectasia-lymphedema syndrome 3 (618154)
Review for gene: ADAMTS3 was set to GREEN
Added comment: Note also in UK PanelApp nonsyndromic lymphedema list. Two papers, independent families. 30450763 paper supplies functional evidence.Should potentially add to syndromic lymphedema list also as dysmorphism reported. 28985353: in vitro and murine data that suggest a close functional interaction between ADAMTS3 and CCBE1 (an established lymphedema gene)
Sources: Expert Review
Lymphoedema_nonsyndromic v0.6 Sue White Panel name changed from Lymphoedema to Lymphoedema_nonsyndromic
Lymphoedema_nonsyndromic v0.5 CELSR1 Zornitza Stark Marked gene: CELSR1 as ready
Lymphoedema_nonsyndromic v0.5 CELSR1 Zornitza Stark Gene: celsr1 has been classified as Green List (High Evidence).
Lymphoedema_nonsyndromic v0.5 CELSR1 Sue White Classified gene: CELSR1 as Green List (high evidence)
Lymphoedema_nonsyndromic v0.5 CELSR1 Sue White Gene: celsr1 has been classified as Green List (High Evidence).
Lymphoedema_nonsyndromic v0.4 CELSR1 Sue White gene: CELSR1 was added
gene: CELSR1 was added to Lymphoedema. Sources: Literature
Mode of inheritance for gene: CELSR1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications for gene: CELSR1 were set to 31215153
Phenotypes for gene: CELSR1 were set to lymphoedema
Penetrance for gene: CELSR1 were set to Incomplete
Review for gene: CELSR1 was set to GREEN
Added comment: nonsyndromic lymphoedema
LOF variants
Sources: Literature
Lymphoedema_nonsyndromic v0.3 PTPN14 Zornitza Stark Marked gene: PTPN14 as ready
Lymphoedema_nonsyndromic v0.3 PTPN14 Zornitza Stark Gene: ptpn14 has been classified as Green List (High Evidence).
Lymphoedema_nonsyndromic v0.3 PTPN14 Zornitza Stark Classified gene: PTPN14 as Green List (high evidence)
Lymphoedema_nonsyndromic v0.3 PTPN14 Zornitza Stark Gene: ptpn14 has been classified as Green List (High Evidence).
Lymphoedema_nonsyndromic v0.2 PTPN14 Bryony Thompson gene: PTPN14 was added
gene: PTPN14 was added to Lymphoedema. Sources: Expert list
Mode of inheritance for gene: PTPN14 was set to BIALLELIC, autosomal or pseudoautosomal
Publications for gene: PTPN14 were set to 20826270; https://doi.org/10.1016/j.mgene.2017.07.006
Phenotypes for gene: PTPN14 were set to Choanal atresia and lymphedema MIM#613611
Review for gene: PTPN14 was set to GREEN
Added comment: Two unrelated consanguineous middle eastern families reported with choanal atresia and lymphedema, and different homozygous variants. The Ptpn14-/- mouse model manifects lymphatic hyperplasia with lymphedema.
Sources: Expert list
Lymphoedema_nonsyndromic v0.1 Zornitza Stark Panel name changed from Lymphedema_VCGS to Lymphoedema
Panel types changed to Victorian Clinical Genetics Services
Lymphoedema_nonsyndromic v0.0 VEGFC Zornitza Stark gene: VEGFC was added
gene: VEGFC was added to Lymphedema_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: VEGFC was set to Unknown
Lymphoedema_nonsyndromic v0.0 SOX18 Zornitza Stark gene: SOX18 was added
gene: SOX18 was added to Lymphedema_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: SOX18 was set to Unknown
Lymphoedema_nonsyndromic v0.0 PIEZO1 Zornitza Stark gene: PIEZO1 was added
gene: PIEZO1 was added to Lymphedema_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: PIEZO1 was set to Unknown
Lymphoedema_nonsyndromic v0.0 KIF11 Zornitza Stark gene: KIF11 was added
gene: KIF11 was added to Lymphedema_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: KIF11 was set to Unknown
Lymphoedema_nonsyndromic v0.0 IKBKG Zornitza Stark gene: IKBKG was added
gene: IKBKG was added to Lymphedema_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: IKBKG was set to Unknown
Lymphoedema_nonsyndromic v0.0 GJC2 Zornitza Stark gene: GJC2 was added
gene: GJC2 was added to Lymphedema_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: GJC2 was set to Unknown
Lymphoedema_nonsyndromic v0.0 GJA1 Zornitza Stark gene: GJA1 was added
gene: GJA1 was added to Lymphedema_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: GJA1 was set to Unknown
Lymphoedema_nonsyndromic v0.0 GATA2 Zornitza Stark gene: GATA2 was added
gene: GATA2 was added to Lymphedema_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: GATA2 was set to Unknown
Lymphoedema_nonsyndromic v0.0 FOXC2 Zornitza Stark gene: FOXC2 was added
gene: FOXC2 was added to Lymphedema_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: FOXC2 was set to Unknown
Lymphoedema_nonsyndromic v0.0 FLT4 Zornitza Stark gene: FLT4 was added
gene: FLT4 was added to Lymphedema_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: FLT4 was set to Unknown
Lymphoedema_nonsyndromic v0.0 FAT4 Zornitza Stark gene: FAT4 was added
gene: FAT4 was added to Lymphedema_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: FAT4 was set to Unknown
Lymphoedema_nonsyndromic v0.0 EPHB4 Zornitza Stark gene: EPHB4 was added
gene: EPHB4 was added to Lymphedema_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: EPHB4 was set to Unknown
Lymphoedema_nonsyndromic v0.0 CCBE1 Zornitza Stark gene: CCBE1 was added
gene: CCBE1 was added to Lymphedema_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: CCBE1 was set to Unknown
Lymphoedema_nonsyndromic v0.0 Zornitza Stark Added panel Lymphedema_VCGS