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Retinitis pigmentosa_Autosomal Recessive/X-linked v0.152 TMEM216 Zornitza Stark Publications for gene: TMEM216 were set to
Retinitis pigmentosa_Autosomal Recessive/X-linked v0.151 TMEM216 Zornitza Stark edited their review of gene: TMEM216: Changed publications: 39191256
Retinitis pigmentosa_Autosomal Recessive/X-linked v0.151 TMEM216 Zornitza Stark Marked gene: TMEM216 as ready
Retinitis pigmentosa_Autosomal Recessive/X-linked v0.151 TMEM216 Zornitza Stark Gene: tmem216 has been classified as Green List (High Evidence).
Retinitis pigmentosa_Autosomal Recessive/X-linked v0.151 TMEM216 Zornitza Stark Classified gene: TMEM216 as Green List (high evidence)
Retinitis pigmentosa_Autosomal Recessive/X-linked v0.151 TMEM216 Zornitza Stark Gene: tmem216 has been classified as Green List (High Evidence).
Retinitis pigmentosa_Autosomal Recessive/X-linked v0.150 TMEM216 Zornitza Stark gene: TMEM216 was added
gene: TMEM216 was added to Retinitis pigmentosa_Autosomal Recessive/X-linked. Sources: Literature
UTR tags were added to gene: TMEM216.
Mode of inheritance for gene: TMEM216 was set to BIALLELIC, autosomal or pseudoautosomal
Phenotypes for gene: TMEM216 were set to Retinitis pigmentosa, MONDO:0019200, TMEM216-related
Review for gene: TMEM216 was set to GREEN
Added comment: Two rare nucleotide substitutions at the same genomic location on chromosome 11 (g.61392563 [GRCh38]), 69 base pairs upstream of the start codon of the ciliopathy gene TMEM216 (c.-69G>A, c.-69G>T [GenBank: NM_001173991.3]) found in individuals of South Asian and African ancestry, respectively.

This included 71 homozygotes and 3 mixed heterozygotes in trans with a predicted loss-of-function allele. Haplotype analysis showed single-nucleotide variants (SNVs) common across families, suggesting ancestral alleles within the two distinct ethnic populations.

Clinical phenotype analysis of 62 available individuals from 49 families indicated a similar clinical presentation with night blindness in the first decade and progressive peripheral field loss thereafter. No evident systemic ciliopathy features were noted.

Functional characterization of these variants by luciferase reporter gene assay showed reduced promotor activity.
Sources: Literature