| Date | Panel | Item | Activity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Breast Cancer v0.26 | CHEK2 | Zornitza Stark Marked gene: CHEK2 as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Breast Cancer v0.26 | CHEK2 | Zornitza Stark Gene: chek2 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Breast Cancer v0.26 | CHEK2 | Chirag Patel Classified gene: CHEK2 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Breast Cancer v0.26 | CHEK2 | Chirag Patel Gene: chek2 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Breast Cancer v0.1 | CHEK2 |
Chirag Patel gene: CHEK2 was added gene: CHEK2 was added to Breast Cancer. Sources: Expert list,Expert Review,Literature Mode of inheritance for gene: CHEK2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: CHEK2 were set to PMID: 33322746, 36529447 Phenotypes for gene: CHEK2 were set to Breast cancer, MONDO:0007254; CHEK2-related cancer predisposition, MONDO:0700271; Breast/prostate cancer, susceptibility to, MIM#609265 Review for gene: CHEK2 was set to GREEN Added comment: Established gene-disease association. Breast cancers reported in condition. Consider possibility that an identified variant could represent ACE (aberrant clonal expansion), which can be due to clonal haematopoiesis of indeterminate potential (CHIP) or an occult hematologic malignancy, especially in older patients who have undergone prior chemotherapy (PMID: 36040522). Sources: Expert list, Expert Review, Literature |
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