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  3. LHB
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Differences of Sex Development

Gene: LHB

Green List (high evidence)
LHB (luteinizing hormone beta polypeptide)
EnsemblGeneIds (GRCh38): ENSG00000104826
EnsemblGeneIds (GRCh37): ENSG00000104826
OMIM: 152780, Gene2Phenotype
LHB is in 5 panels

1 review

Crystle Lee (Victorian Clinical Genetics Services)

Green List (high evidence)

>3 patients and biallelic variants previously reported with the associated phenotype
Created: 15 Jul 2020, 4:36 a.m. | Last Modified: 15 Jul 2020, 4:36 a.m.
Panel Version: 0.72

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Hypogonadotropic hypogonadism 23 with or without anosmia (MIM#228300)

Publications

Created: 15 Jul 2020, 4:36 a.m.
Last Modified: 15 Jul 2020, 4:36 a.m.
Panel version: 0.72

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
Phenotypes
  • Hypogonadotropic hypogonadism 23 with or without anosmia (MIM#228300)
OMIM
152780
Clinvar variants
Variants in LHB
Penetrance
None
Publications
Panels with this gene

History Filter Activity

15 Jul 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: lhb has been classified as Green List (High Evidence).

15 Jul 2020, Gel status: 3

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: LHB were changed from to Hypogonadotropic hypogonadism 23 with or without anosmia (MIM#228300)

15 Jul 2020, Gel status: 3

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: LHB were set to

15 Jul 2020, Gel status: 3

Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Mode of inheritance for gene: LHB was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: LHB was added gene: LHB was added to Disorders of Sex Differentiation_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services Mode of inheritance for gene: LHB was set to Unknown