1. Panels
  2. Congenital Diarrhoea
  3. WNT2B
STRs in panel
Prev Next
Regions in panel
Prev Next

Congenital Diarrhoea

Gene: WNT2B

Green List (high evidence)
WNT2B (Wnt family member 2B)
EnsemblGeneIds (GRCh38): ENSG00000134245
EnsemblGeneIds (GRCh37): ENSG00000134245
OMIM: 601968, Gene2Phenotype
WNT2B is in 2 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Diarrhoea-9 is a form of neonatal-onset chronic diarrhoea characterized by an osmotic diarrhoea that is not substrate specific, abnormal crypt and villus architecture, and significant fat malabsorption.

Two unrelated families and functional data suggesting severe intestinal dysregulation due to decreased intestinal stem cell number and function.
Created: 4 Jan 2021, 11:46 p.m. | Last Modified: 4 Jan 2021, 11:46 p.m.
Panel Version: 0.38

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Diarrhoea 9, MIM# 618168

Publications

Created: 4 Jan 2021, 11:46 p.m.
Last Modified: 4 Jan 2021, 11:46 p.m.
Panel version: 0.38

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
Phenotypes
  • Diarrhoea 9, MIM# 618168
OMIM
601968
Clinvar variants
Variants in WNT2B
Penetrance
None
Publications
Panels with this gene

History Filter Activity

4 Jan 2021, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: wnt2b has been classified as Green List (High Evidence).

4 Jan 2021, Gel status: 3

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: WNT2B were changed from to Diarrhoea 9, MIM# 618168

4 Jan 2021, Gel status: 3

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: WNT2B were set to

4 Jan 2021, Gel status: 3

Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Mode of inheritance for gene: WNT2B was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: WNT2B was added gene: WNT2B was added to Congenital Diarrhoea_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services Mode of inheritance for gene: WNT2B was set to Unknown