1. Panels
  2. Ciliary Dyskinesia
  3. TTC25
STRs in panel
Prev Next
Regions in panel
Prev Next

Ciliary Dyskinesia

Gene: TTC25

Green List (high evidence)
TTC25 (tetratricopeptide repeat domain 25)
EnsemblGeneIds (GRCh38): ENSG00000204815
EnsemblGeneIds (GRCh37): ENSG00000204815
OMIM: 617095, Gene2Phenotype
TTC25 is in 5 panels

3 reviews

Sangavi Sivagnanasundram (Melbourne Health)

New HGNC gene name - ODAD4 (HGNC:25280)
Created: 6 May 2024, 12:37 a.m. | Last Modified: 6 May 2024, 12:37 a.m.
Panel Version: 1.39

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
primary ciliary dyskinesia 35 MONDO:0014910

Publications

  • https://search.clinicalgenome.org/CCID:005700

Created: 6 May 2024, 12:37 a.m.
Last Modified: 6 May 2024, 12:37 a.m.
Panel version: 1.39

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Biallelic variants cause a primary ciliary dyskinesia - at least 7 unrelated families reported in literature
Created: 14 Jul 2022, 8:37 a.m. | Last Modified: 14 Jul 2022, 8:37 a.m.
Panel Version: 1.18

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Ciliary dyskinesia, primary, 35, OMIM:617092

Publications

Created: 14 Jul 2022, 8:37 a.m.
Last Modified: 14 Jul 2022, 8:37 a.m.
Panel version: 1.18

Crystle Lee (Victorian Clinical Genetics Services)

I don't know

2 families reported with PCD. Mouse model showed immotile nodal cilia. Left as amber for now.

Gene ncodes a component of the outer dynein arm required to develop the main mechanical force to generate ciliary beats
(Gene is non coding in gnomad v2 and coding in v3)
Sources: Expert Review
Created: 6 May 2020, 12:19 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Ciliary dyskinesia, primary, 35 (MIM#617092)

Publications

Created: 6 May 2020, 12:19 a.m.

Panel version: 0.45

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
Phenotypes
  • Ciliary dyskinesia, primary, 35 (MIM#617092)
Tags
new gene name
OMIM
617095
Clinvar variants
Variants in TTC25
Penetrance
None
Publications
Panels with this gene

History Filter Activity

7 May 2024, Gel status: 3

Added Tag

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Tag new gene name tag was added to gene: TTC25.

14 Jul 2022, Gel status: 3

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: TTC25 were set to 27486780

14 Jul 2022, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: ttc25 has been classified as Green List (High Evidence).

6 May 2020, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: ttc25 has been classified as Amber List (Moderate Evidence).

6 May 2020, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: ttc25 has been classified as Amber List (Moderate Evidence).

6 May 2020, Gel status: 0

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Crystle Lee (Victorian Clinical Genetics Services)

gene: TTC25 was added gene: TTC25 was added to Ciliary Dyskinesia. Sources: Expert Review Mode of inheritance for gene: TTC25 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: TTC25 were set to 27486780 Phenotypes for gene: TTC25 were set to Ciliary dyskinesia, primary, 35 (MIM#617092) Review for gene: TTC25 was set to AMBER