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  3. ICOS
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Cataract

Gene: ICOS

Red List (low evidence)
ICOS (inducible T-cell costimulator)
EnsemblGeneIds (GRCh38): ENSG00000163600
EnsemblGeneIds (GRCh37): ENSG00000163600
OMIM: 604558, Gene2Phenotype
ICOS is in 9 panels

1 review

Lauren Akesson (Royal Melbourne Hospital)

Red List (low evidence)

Cataracts are not a typical feature of CVID.
Created: 6 Apr 2020, 1:35 a.m. | Last Modified: 6 Apr 2020, 1:35 a.m.
Panel Version: 0.60

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Common variable immunodeficiency 1 (604558)

Created: 6 Apr 2020, 1:35 a.m.
Last Modified: 6 Apr 2020, 1:35 a.m.
Panel version: 0.60

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Red
  • Victorian Clinical Genetics Services
Phenotypes
  • Common variable immunodeficiency 1 (604558)
OMIM
604558
Clinvar variants
Variants in ICOS
Penetrance
None
Panels with this gene

History Filter Activity

6 Apr 2020, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: icos has been classified as Red List (Low Evidence).

6 Apr 2020, Gel status: 1

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: ICOS were changed from to Common variable immunodeficiency 1 (604558)

6 Apr 2020, Gel status: 1

Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Mode of inheritance for gene: ICOS was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal

6 Apr 2020, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: icos has been classified as Red List (Low Evidence).

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: ICOS was added gene: ICOS was added to Cataract_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services Mode of inheritance for gene: ICOS was set to Unknown