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  2. Congenital anomalies of the kidney and urinary tract (CAKUT) Syndromic
  3. WLS
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Congenital anomalies of the kidney and urinary tract (CAKUT) Syndromic

Gene: WLS

Green List (high evidence)
WLS (wntless Wnt ligand secretion mediator)
EnsemblGeneIds (GRCh38): ENSG00000116729
EnsemblGeneIds (GRCh37): ENSG00000116729
OMIM: 611514, Gene2Phenotype
WLS is in 6 panels

2 reviews

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Zaki syndrome, MIM#619648

Created: 6 Dec 2021, 9:44 p.m.
Last Modified: 6 Dec 2021, 9:44 p.m.
Panel version: 0.98

Teresa Zhao (Victorian Clinical Genetics Services)

Green List (high evidence)

- Homozygous mutations in 10 affected persons from 5 unrelated families.
- Patients had multiorgan defects, including microcephal, facial dysmorphism, foot syndactyly, renal agenesis, alopecia, iris coloboma, and heart defects.
- The mutations affected WLS protein stability and Wnt signaling. Knock-in mice showed tissue and cell vulnerability consistent with Wnt-signaling intensity and individual and collective functions of Wnts in embryogenesis.
Sources: Literature
Created: 4 Oct 2021, 4:44 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Syndromic structural birth defects

Publications

Created: 4 Oct 2021, 4:44 a.m.

Panel version: 0.88

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
Phenotypes
  • Zaki syndrome, MIM#619648
OMIM
611514
Clinvar variants
Variants in WLS
Penetrance
None
Publications
Panels with this gene

History Filter Activity

6 Dec 2021, Gel status: 3

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: WLS were changed from Syndromic structural birth defects to Zaki syndrome, MIM#619648

4 Oct 2021, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: wls has been classified as Green List (High Evidence).

4 Oct 2021, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: wls has been classified as Green List (High Evidence).

4 Oct 2021, Gel status: 0

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Teresa Zhao (Victorian Clinical Genetics Services)

gene: WLS was added gene: WLS was added to Congenital anomalies of the kidney and urinary tract (CAKUT) Syndromic. Sources: Literature Mode of inheritance for gene: WLS was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: WLS were set to PMID: 34587386 Phenotypes for gene: WLS were set to Syndromic structural birth defects Review for gene: WLS was set to GREEN