Bleeding and Platelet Disorders

Gene: F10

Green List (high evidence)

F10 (coagulation factor X)
EnsemblGeneIds (GRCh38): ENSG00000126218
EnsemblGeneIds (GRCh37): ENSG00000126218
OMIM: 613872, Gene2Phenotype
F10 is in 5 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Factor X deficiency shows variable phenotypic severity. Affected individuals can manifest prolonged nasal and mucosal haemorrhage, menorrhagia, haematuria, and occasionally haemarthrosis.

More than 20 unrelated families reported.
Created: 2 Jun 2021, 9:47 a.m. | Last Modified: 2 Jun 2021, 9:47 a.m.
Panel Version: 0.237

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Factor X deficiency, MIM# 227600; MONDO:0009212

Publications

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
Phenotypes
  • Factor X deficiency, MIM# 227600
  • MONDO:0009212
OMIM
613872
Clinvar variants
Variants in F10
Penetrance
None
Publications
Panels with this gene

History Filter Activity

2 Jun 2021, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: f10 has been classified as Green List (High Evidence).

2 Jun 2021, Gel status: 3

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: F10 were changed from to Factor X deficiency, MIM# 227600; MONDO:0009212

2 Jun 2021, Gel status: 3

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: F10 were set to

2 Jun 2021, Gel status: 3

Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Mode of inheritance for gene: F10 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: F10 was added gene: F10 was added to Bleeding Disorders_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services Mode of inheritance for gene: F10 was set to Unknown