1. Panels
  2. Prostate Cancer
  3. HOXB13
STRs in panel
Prev Next
Regions in panel
Prev Next

Prostate Cancer

Gene: HOXB13

Green List (high evidence)
HOXB13 (homeobox B13)
EnsemblGeneIds (GRCh38): ENSG00000159184
EnsemblGeneIds (GRCh37): ENSG00000159184
OMIM: 604607, Gene2Phenotype
HOXB13 is in 2 panels

1 review

Chirag Patel (Genetic Health Queensland)

Green List (high evidence)

Established gene-disease association (particularly G84E variant).

Several studies demonstrating the association of the HOXB13 G84E variant with prostate cancer, including a European study that showed an increased frequency of the HOXB13 G84E variant in patients with prostate cancer at 1.4% compared to those without prostate cancer at 0.1%.
Sources: Expert list, Expert Review, Literature
Created: 18 Sep 2024, 11:06 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Prostate cancer, MONDO:0008315; Prostate cancer, susceptibility to, MIM#610997

Publications

Created: 18 Sep 2024, 11:06 p.m.

Panel version: 0.23

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Literature
  • Expert Review
  • Expert list
Phenotypes
  • Prostate cancer, MONDO:0008315
  • Prostate cancer, susceptibility to, MIM#610997
OMIM
604607
Clinvar variants
Variants in HOXB13
Penetrance
None
Publications
Panels with this gene

History Filter Activity

9 Oct 2024, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: hoxb13 has been classified as Green List (High Evidence).

18 Sep 2024, Gel status: 3

Entity classified by Genomics England curator

Chirag Patel (Genetic Health Queensland)

Gene: hoxb13 has been classified as Green List (High Evidence).

18 Sep 2024, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Chirag Patel (Genetic Health Queensland)

gene: HOXB13 was added gene: HOXB13 was added to Prostate Cancer. Sources: Expert list,Expert Review,Literature Mode of inheritance for gene: HOXB13 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: HOXB13 were set to PMID: 22236224, 30730552, 38766261 Phenotypes for gene: HOXB13 were set to Prostate cancer, MONDO:0008315; Prostate cancer, susceptibility to, MIM#610997 Review for gene: HOXB13 was set to GREEN