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  2. Prostate Cancer

Prostate Cancer (Version 1.1)

Level 2: Cancer Predisposition

Panel types: Victorian Clinical Genetics Services, Genetic Health Queensland, Cancer Germline, Adult Genetics Unit, Royal Adelaide Hospital
Description
This panel contains genes associated with prostate cancer. 

Further information on the testing criteria for prostate cancer can be found at eviQ: 
https://www.eviq.org.au/cancer-genetics/adult/genetic-testing-using-cancer-gene-panels/3648-prostate-cancer-panel-testing

Only ‘Green’ genes should be tested and analysed for clinical testing, as they have sufficient peer-reviewed published evidence of association with prostate cancer and are clinically actionable for diagnostic and/or predictive genetic testing.

Ensure testing includes copy number variant (CNV) analysis, as CNVs contribute to a clinically significant proportion of pathogenic variants associated with familial risk of cancer.

This panel has been compared against the Genomics England PanelApp and aligned with any assessments by ClinGen.

This panel has been developed under the guidance of experts in cancer genetics (Dr Helen Mar Fan and Dr Nicola Poplawski).
Panel Activity

1 reviewer

  • Chirag Patel (Genetic Health Queensland)

12 Entities

12 reviewed, 12 green

List Entity Reviews Mode of inheritance Details
12 Entitiess
Green List (high evidence)
ATM
1 review
1 green
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert list
  • Expert Review
  • Expert Review Green
Phenotypes
  • Prostate cancer, MONDO:0008315
  • ATM-related cancer predisposition, MONDO:0700270
  • Breast cancer, susceptibility to, MIM#114480
Tags
Green List (high evidence)
BRCA1
1 review
1 green
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert list
  • Expert Review
  • Expert Review Green
Phenotypes
  • Prostate cancer, MONDO:0008315
  • BRCA1-related cancer predisposition, MONDO:0700268
  • Breast-ovarian cancer, familial, 1, MIM#604370
Tags
Green List (high evidence)
BRCA2
1 review
1 green
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert list
  • Expert Review
  • Expert Review Green
Phenotypes
  • Prostate cancer, MONDO:0008315
  • BRCA2-related cancer predisposition, MONDO:0700269
  • Breast-ovarian cancer, familial, 2, MIM#612555
Tags
Green List (high evidence)
CHEK2
1 review
1 green
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert list
  • Expert Review
  • Expert Review Green
  • Literature
Phenotypes
  • Prostate cancer, MONDO:0008315
  • CHEK2-related cancer predisposition, MONDO:0700271
  • Breast/prostate cancer, susceptibility to, MIM#609265
Tags
Green List (high evidence)
EPCAM
1 review
1 green
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert list
  • Expert Review
  • Expert Review Green
Phenotypes
  • Prostate cancer, MONDO:0008315
  • Lynch syndrome 8, MONDO:0013196
  • Lynch syndrome 8, MIM#613244
Tags
Green List (high evidence)
HOXB13
1 review
1 green
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert list
  • Expert Review
  • Expert Review Green
  • Literature
Phenotypes
  • Prostate cancer, MONDO:0008315
  • Prostate cancer, susceptibility to, MIM#610997
Tags
Green List (high evidence)
MLH1
1 review
1 green
BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Sources
  • Expert list
  • Expert Review
  • Expert Review Green
Phenotypes
  • Prostate cancer, MONDO:0008315
  • Lynch syndrome 2, MONDO:0012249
  • Mismatch repair cancer syndrome 1, MONDO:0010159
  • Lynch syndrome 2, MIM#609310
  • Mismatch repair cancer syndrome 1, MIM#276300
Tags
Green List (high evidence)
MSH2
1 review
1 green
BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Sources
  • Expert list
  • Expert Review
  • Expert Review Green
Phenotypes
  • Prostate cancer, MONDO:0008315
  • Lynch syndrome 1, MONDO:0007356
  • Mismatch repair cancer syndrome 2, MONDO:0030840
  • Lynch syndrome 1, MIM#120435
  • Mismatch repair cancer syndrome 2, MIM#619096
Tags
Green List (high evidence)
MSH6
1 review
1 green
BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Sources
  • Expert list
  • Expert Review
  • Expert Review Green
Phenotypes
  • Prostate cancer, MONDO:0008315
  • Lynch syndrome 5, MONDO:0013710
  • Mismatch repair cancer syndrome 3, MONDO:0030841
  • Lynch syndrome 5, MIM#614350
  • Mismatch repair cancer syndrome 3, MIM#619097
Tags
Green List (high evidence)
PALB2
1 review
1 green
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert list
  • Expert Review
  • Expert Review Green
Phenotypes
  • Prostate cancer, MONDO:0008315
  • PALB2-related cancer predisposition, MONDO:0700272
  • Breast-ovarian cancer, familial, susceptibility to, 5, MIM#620442
  • Pancreatic cancer, susceptibility to, 3, MIM#613348
Tags
Green List (high evidence)
PMS2
1 review
1 green
BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Sources
  • Expert list
  • Expert Review
  • Expert Review Green
Phenotypes
  • Prostate cancer, MONDO:0008315
  • Lynch syndrome 4, MONDO:0013699
  • Mismatch repair cancer syndrome 4, MONDO:0030843
  • Lynch syndrome 4, MIM#614337
  • Mismatch repair cancer syndrome 4, MIM#619101
Tags
Green List (high evidence)
TP53
1 review
1 green
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert list
  • Expert Review
  • Expert Review Green
Phenotypes
  • Prostate cancer, MONDO:0008315
  • Li-Fraumeni syndrome, MONDO:0018875
  • Li-Fraumeni syndrome, MIM#151623
Tags

Major version comments

  • 2024-10-09 03:34 Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics) promoted panel to 1.0
    Promoted to V1.

Downloads

Download lists

  • Whole panel
  • Green list (high evidence)
  • Green and Amber Genes
  • Amber Genes
  • Red list (low evidence)

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