Pancreatic Cancer
Gene: TP53
ClinGen definitive. Pancreatic cancer reported in condition.
Consider possibility that an identified variant could represent ACE (aberrant clonal expansion), which can be due to clonal haematopoiesis of indeterminate potential (CHIP) or an occult hematologic malignancy, especially in older patients who have undergone prior chemotherapy (PMID: 36040522).
Sources: Expert list, Expert ReviewCreated: 12 Sep 2024, 9:22 p.m. | Last Modified: 13 Sep 2024, 1:25 a.m.
Panel Version: 0.24
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Malignant pancreatic neoplasm, MONDO:0009831; Li-Fraumeni syndrome, MONDO:0018875; Li-Fraumeni syndrome, MIM#151623
Gene: tp53 has been classified as Green List (High Evidence).
Gene: tp53 has been classified as Green List (High Evidence).
gene: TP53 was added gene: TP53 was added to Pancreatic Cancer. Sources: Expert list,Expert Review Mode of inheritance for gene: TP53 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: TP53 were set to Malignant pancreatic neoplasm, MONDO:0009831; Li-Fraumeni syndrome, MONDO:0018875; Li-Fraumeni syndrome, MIM#151623 Review for gene: TP53 was set to GREEN