Pancreatic Cancer
Gene: PALB2EnsemblGeneIds (GRCh38): ENSG00000083093
EnsemblGeneIds (GRCh37): ENSG00000083093
OMIM: 610355, Gene2Phenotype
PALB2 is in 18 panels
1 review
Chirag Patel (Genetic Health Queensland)
ClinGen definitive. Pancreatic cancer reported in condition.
Sources: Expert list, Expert ReviewCreated: 12 Sep 2024, 9:23 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Malignant pancreatic neoplasm, MONDO:0009831; PALB2-related cancer predisposition, MONDO:0700272; Breast-ovarian cancer, familial, susceptibility to, 5, MIM#620442; Pancreatic cancer, susceptibility to, 3, MIM#613348
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
- Sources
-
- Expert Review Green
- Expert Review
- Expert list
- Phenotypes
-
- Malignant pancreatic neoplasm, MONDO:0009831
- PALB2-related cancer predisposition, MONDO:0700272
- Breast-ovarian cancer, familial, susceptibility to, 5, MIM#620442
- Pancreatic cancer, susceptibility to, 3, MIM#613348
- OMIM
- 610355
- Clinvar variants
- Variants in PALB2
- Penetrance
- None
- Panels with this gene
-
- Chromosome Breakage Disorders
- Additional findings_Adult
- Prostate Cancer
- Breast Cancer
- Ovarian Cancer
- Incidentalome_PREGEN_DRAFT
- Pancreatic Cancer
- Bone Marrow Failure
- BabyScreen+ newborn screening
- Transplant Co-Morbidity Superpanel
- Cancer Predisposition_Paediatric
- Radial Ray Abnormalities
- Incidentalome
- Fetal anomalies
- Additional findings_Paediatric
- IBMDx study
- Wilms Tumour
- Growth failure
History Filter Activity
Entity classified by Genomics England curator
Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)Gene: palb2 has been classified as Green List (High Evidence).
Entity classified by Genomics England curator
Chirag Patel (Genetic Health Queensland)Gene: palb2 has been classified as Green List (High Evidence).
Created, Added New Source, Set mode of inheritance, Set Phenotypes
Chirag Patel (Genetic Health Queensland)gene: PALB2 was added gene: PALB2 was added to Pancreatic Cancer. Sources: Expert list,Expert Review Mode of inheritance for gene: PALB2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: PALB2 were set to Malignant pancreatic neoplasm, MONDO:0009831; PALB2-related cancer predisposition, MONDO:0700272; Breast-ovarian cancer, familial, susceptibility to, 5, MIM#620442; Pancreatic cancer, susceptibility to, 3, MIM#613348 Review for gene: PALB2 was set to GREEN