Pancreatic Cancer
Gene: MSH2
ClinGen definitive. Pancreatic cancer reported in condition.
Sources: Expert list, Expert ReviewCreated: 12 Sep 2024, 9:18 p.m.
Mode of inheritance
BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Phenotypes
Malignant pancreatic neoplasm, MONDO:0009831; Lynch syndrome 1, MONDO:0007356; Mismatch repair cancer syndrome 2, MONDO:0030840; Lynch syndrome 1, MIM#120435; Mismatch repair cancer syndrome 2, MIM#619096
Gene: msh2 has been classified as Green List (High Evidence).
Gene: msh2 has been classified as Green List (High Evidence).
gene: MSH2 was added gene: MSH2 was added to Pancreatic Cancer. Sources: Expert list,Expert Review Mode of inheritance for gene: MSH2 was set to BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal Phenotypes for gene: MSH2 were set to Malignant pancreatic neoplasm, MONDO:0009831; Lynch syndrome 1, MONDO:0007356; Mismatch repair cancer syndrome 2, MONDO:0030840; Lynch syndrome 1, MIM#120435; Mismatch repair cancer syndrome 2, MIM#619096 Review for gene: MSH2 was set to GREEN