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  2. Diffuse Gastric Cancer
  3. CTNNA1
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Diffuse Gastric Cancer

Gene: CTNNA1

Green List (high evidence)
CTNNA1 (catenin alpha 1)
EnsemblGeneIds (GRCh38): ENSG00000044115
EnsemblGeneIds (GRCh37): ENSG00000044115
OMIM: 116805, Gene2Phenotype
CTNNA1 is in 4 panels

1 review

Chirag Patel (Genetic Health Queensland)

Green List (high evidence)

ClinGen definitive.
Sources: Expert list, Expert Review
Created: 12 Sep 2024, 4:03 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Diffuse gastric cancer, MONDO:0957519; CTNNA1-related diffuse gastric and lobular breast cancer syndrome, MONDO:0100256; no MIM#

Created: 12 Sep 2024, 4:03 a.m.

Panel version: 0.2

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Expert Review
  • Expert list
Phenotypes
  • Diffuse gastric cancer, MONDO:0957519
  • CTNNA1-related diffuse gastric and lobular breast cancer syndrome, MONDO:0100256
  • no MIM#
OMIM
116805
Clinvar variants
Variants in CTNNA1
Penetrance
None
Panels with this gene

History Filter Activity

9 Oct 2024, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: ctnna1 has been classified as Green List (High Evidence).

12 Sep 2024, Gel status: 3

Entity classified by Genomics England curator

Chirag Patel (Genetic Health Queensland)

Gene: ctnna1 has been classified as Green List (High Evidence).

12 Sep 2024, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Chirag Patel (Genetic Health Queensland)

gene: CTNNA1 was added gene: CTNNA1 was added to Diffuse Gastric Cancer. Sources: Expert list,Expert Review Mode of inheritance for gene: CTNNA1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: CTNNA1 were set to Diffuse gastric cancer, MONDO:0957519; CTNNA1-related diffuse gastric and lobular breast cancer syndrome, MONDO:0100256; no MIM# Review for gene: CTNNA1 was set to GREEN