Wilms Tumour

Gene: TP53

Red List (low evidence)

TP53 (tumor protein p53)
EnsemblGeneIds (GRCh38): ENSG00000141510
EnsemblGeneIds (GRCh37): ENSG00000141510
OMIM: 191170, Gene2Phenotype
TP53 is in 18 panels

1 review

Chirag Patel (Genetic Health Queensland)

Red List (low evidence)

ClinGen definitive. Limited evidence for presentation with Wilms tumour in disease.
Sources: Expert list, Expert Review
Created: 26 Sep 2024, 1:50 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Wilms tumor, MONDO:0006058; Li-Fraumeni syndrome, MONDO:0018875; Li-Fraumeni syndrome, MIM#151623

History Filter Activity

9 Oct 2024, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: tp53 has been classified as Red List (Low Evidence).

26 Sep 2024, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Chirag Patel (Genetic Health Queensland)

gene: TP53 was added gene: TP53 was added to Wilms Tumour. Sources: Expert list,Expert Review Mode of inheritance for gene: TP53 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: TP53 were set to Wilms tumor, MONDO:0006058; Li-Fraumeni syndrome, MONDO:0018875; Li-Fraumeni syndrome, MIM#151623 Review for gene: TP53 was set to RED