Entity Name	Entity type	Gene Symbol	Sources(; separated)	Level4	Level3	Level2	Model_Of_Inheritance	Phenotypes	Omim	Orphanet	HPO	Publications	Description	Flagged	GEL_Status	UserRatings_Green_amber_red	version	ready	Mode of pathogenicity	EnsemblId(GRch37)	EnsemblId(GRch38)	HGNC	Position Chromosome	Position GRCh37 Start	Position GRCh37 End	Position GRCh38 Start	Position GRCh38 End	STR Repeated Sequence	STR Normal Repeats	STR Pathogenic Repeats	Region Haploinsufficiency Score	Region Triplosensitivity Score	Region Required Overlap Percentage	Region Variant Type	Region Verbose Name
AMER1	gene	AMER1	Expert list;Expert Review;Expert Review Red;Literature	Wilms Tumour		Cancer Predisposition	X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)	Wilms tumor, MONDO:0006058;Osteopathia striata with cranial sclerosis, MONDO:0010310;Osteopathia striata with cranial sclerosis. MIM#300373			Nephroblastoma;HP:0002667	PMID: 32879452		False	1	0;0;100	1.0	True		ENSG00000184675	ENSG00000184675	HGNC:26837													
ASXL1	gene	ASXL1	Expert list;Expert Review;Expert Review Red	Wilms Tumour		Cancer Predisposition	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Wilms tumor, MONDO:0006058;Bohring-Opitz syndrome, MONDO:0011510;Bohring-Opitz syndrome, MIM#605039			Nephroblastoma;HP:0002667			False	1	0;0;100	1.0	True		ENSG00000171456	ENSG00000171456	HGNC:18318													
CDC73	gene	CDC73	Expert list;Expert Review;Expert Review Red;Literature	Wilms Tumour		Cancer Predisposition	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Wilms tumor, MONDO:0006058;Hyperparathyroidism 2 with jaw tumors, MONDO:0007768;Hyperparathyroidism-jaw tumor syndrome, MIM#145001;Hyperparathyroidism, familial primary, MIM#145000			Nephroblastoma;HP:0002667	PMID: 37339334, 7912571, 7717405		False	1	0;0;100	1.0	True		ENSG00000134371	ENSG00000134371	HGNC:16783													
CTCF	gene	CTCF	Expert list;Expert Review;Expert Review Red;Literature	Wilms Tumour		Cancer Predisposition	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Wilms tumor, MONDO:0006058;Intellectual developmental disorder, autosomal dominant 21, MIM#615502			Nephroblastoma;HP:0002667	PMID: 31239556, 35459888, 36454652		False	1	0;0;100	1.0	True		ENSG00000102974	ENSG00000102974	HGNC:13723													
PIK3CA	gene	PIK3CA	Expert list;Expert Review;Expert Review Red	Wilms Tumour		Cancer Predisposition	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Wilms tumor, MONDO:0006058;PIK3CA-related overgrowth spectrum, MONDO:1040002;PIK3CA-related overgrowth syndrome, multiple MIM#			Nephroblastoma;HP:0002667			False	1	0;0;100	1.0	True	Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments	ENSG00000121879	ENSG00000121879	HGNC:8975													
TP53	gene	TP53	Expert list;Expert Review;Expert Review Red	Wilms Tumour		Cancer Predisposition	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Wilms tumor, MONDO:0006058;Li-Fraumeni syndrome, MONDO:0018875;Li-Fraumeni syndrome, MIM#151623			Nephroblastoma;HP:0002667			False	1	0;0;100	1.0	True		ENSG00000141510	ENSG00000141510	HGNC:11998