1. Panels
  2. Sarcoma soft tissue
  3. DICER1
STRs in panel
Prev Next
Regions in panel
Prev Next

Sarcoma soft tissue

Gene: DICER1

Green List (high evidence)
DICER1 (dicer 1, ribonuclease III)
EnsemblGeneIds (GRCh38): ENSG00000100697
EnsemblGeneIds (GRCh37): ENSG00000100697
OMIM: 606241, Gene2Phenotype
DICER1 is in 8 panels

1 review

Chirag Patel (Genetic Health Queensland)

Green List (high evidence)

ClinGen definitive. Soft-tissue sarcomas reported in condition.
Sources: Expert list, Expert Review
Created: 17 Sep 2024, 10:51 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Soft tissue sarcoma, MONDO:0018078; Sarcoma, MONDO:0005089; DICER1-related tumor predisposition, MONDO:0100216; DICER1 syndrome, MIM#601200

Created: 17 Sep 2024, 10:51 p.m.

Panel version: 0.15

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Expert Review
  • Expert list
Phenotypes
  • Soft tissue sarcoma, MONDO:0018078
  • Sarcoma, MONDO:0005089
  • DICER1-related tumor predisposition, MONDO:0100216
  • DICER1 syndrome, MIM#601200
OMIM
606241
Clinvar variants
Variants in DICER1
Penetrance
None
Panels with this gene

History Filter Activity

9 Oct 2024, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: dicer1 has been classified as Green List (High Evidence).

17 Sep 2024, Gel status: 3

Entity classified by Genomics England curator

Chirag Patel (Genetic Health Queensland)

Gene: dicer1 has been classified as Green List (High Evidence).

17 Sep 2024, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Chirag Patel (Genetic Health Queensland)

gene: DICER1 was added gene: DICER1 was added to Sarcoma soft tissue. Sources: Expert list,Expert Review Mode of inheritance for gene: DICER1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: DICER1 were set to Soft tissue sarcoma, MONDO:0018078; Sarcoma, MONDO:0005089; DICER1-related tumor predisposition, MONDO:0100216; DICER1 syndrome, MIM#601200 Review for gene: DICER1 was set to GREEN