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Meningioma

Gene: NF2

Green List (high evidence)
NF2 (neurofibromin 2)
EnsemblGeneIds (GRCh38): ENSG00000186575
EnsemblGeneIds (GRCh37): ENSG00000186575
OMIM: 607379, Gene2Phenotype
NF2 is in 11 panels

1 review

Chirag Patel (Genetic Health Queensland)

Green List (high evidence)

ClinGen definitive. Meningiomas reported in condition.
Sources: Expert list, Expert Review
Created: 12 Sep 2024, 12:59 a.m. | Last Modified: 12 Sep 2024, 2:57 a.m.
Panel Version: 0.10

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Meningioma, MONDO:0016642; Neurofibromatosis type 2, MONDO:0007039; Neurofibromatosis, type 2, MIM#607174

Variants in this GENE are reported as part of current diagnostic practice

Created: 12 Sep 2024, 12:59 a.m.
Last Modified: 12 Sep 2024, 2:57 a.m.
Panel version: 0.2

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Expert Review
  • Expert list
Phenotypes
  • Meningioma, MONDO:0016642
  • Neurofibromatosis type 2, MONDO:0007039
  • Neurofibromatosis, type 2, MIM#607174
OMIM
607379
Clinvar variants
Variants in NF2
Penetrance
None
Panels with this gene

History Filter Activity

9 Oct 2024, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: nf2 has been classified as Green List (High Evidence).

12 Sep 2024, Gel status: 3

Entity classified by Genomics England curator

Chirag Patel (Genetic Health Queensland)

Gene: nf2 has been classified as Green List (High Evidence).

12 Sep 2024, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Chirag Patel (Genetic Health Queensland)

gene: NF2 was added gene: NF2 was added to Meningioma. Sources: Expert list,Expert Review Mode of inheritance for gene: NF2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: NF2 were set to Meningioma, MONDO:0016642; Neurofibromatosis type 2, MONDO:0007039; Neurofibromatosis, type 2, MIM#607174 Review for gene: NF2 was set to GREEN gene: NF2 was marked as current diagnostic