Entity Name	Entity type	Gene Symbol	Sources(; separated)	Level4	Level3	Level2	Model_Of_Inheritance	Phenotypes	Omim	Orphanet	HPO	Publications	Description	Flagged	GEL_Status	UserRatings_Green_amber_red	version	ready	Mode of pathogenicity	EnsemblId(GRch37)	EnsemblId(GRch38)	HGNC	Position Chromosome	Position GRCh37 Start	Position GRCh37 End	Position GRCh38 Start	Position GRCh38 End	STR Repeated Sequence	STR Normal Repeats	STR Pathogenic Repeats	Region Haploinsufficiency Score	Region Triplosensitivity Score	Region Required Overlap Percentage	Region Variant Type	Region Verbose Name
COL3A1	gene	COL3A1	Expert Review Green;Literature	Spontaneous coronary artery dissection		Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	"Ehlers-Danlos syndrome, vascular type	MIM#130050"				30071989;39130004;32897753;35234813		False	3	100;0;0	0.56	True		ENSG00000168542	ENSG00000168542	HGNC:2201													
COL4A1	gene	COL4A1	Expert Review Green;Other	Spontaneous coronary artery dissection		Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps, MIM#611773				PMID: 35583931, 35234813, 37248441		False	3	100;0;0	0.56	True		ENSG00000187498	ENSG00000187498	HGNC:2202													
COL5A1	gene	COL5A1	Expert Review Green;Literature	Spontaneous coronary artery dissection		Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	"Ehlers-Danlos syndrome, classic type, 1	MIM#130000;Fibromuscular dysplasia, multifocal	MIM#619329"				32938213		False	3	100;0;0	0.56	True		ENSG00000130635	ENSG00000130635	HGNC:2209													
FBN1	gene	FBN1	Expert Review Green;Literature	Spontaneous coronary artery dissection		Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	"Marfan syndrome	MIM#154700;familial thoracic aortic aneurysm and aortic dissection MONDO:0019625, FBN1-related"				29357934		False	3	100;0;0	0.56	True		ENSG00000166147	ENSG00000166147	HGNC:3603													
SMAD2	gene	SMAD2	Expert Review Green;Literature	Spontaneous coronary artery dissection		Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Loeys-Dietz syndrome 6, MIM# 619656				32897753;30448172		False	3	100;0;0	0.56	True		ENSG00000175387	ENSG00000175387	HGNC:6768													
SMAD3	gene	SMAD3	Expert Review Green;Literature	Spontaneous coronary artery dissection		Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Loeys-Dietz syndrome 3, MIM# 613795				21217753;30661052;30071989		False	3	100;0;0	0.56	True		ENSG00000166949	ENSG00000166949	HGNC:6769													
TGFB2	gene	TGFB2	Expert Review Green;Literature	Spontaneous coronary artery dissection		Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	"Loeys-Dietz syndrome 4	MIM#614816"				33125268;36103205		False	3	100;0;0	0.56	True		ENSG00000092969	ENSG00000092969	HGNC:11768													
TGFB3	gene	TGFB3	Expert Review Green;Literature	Spontaneous coronary artery dissection		Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Loeys-Dietz syndrome 5 MIM#615582				32897753		False	3	100;0;0	0.56	True		ENSG00000119699	ENSG00000119699	HGNC:11769													
TGFBR2	gene	TGFBR2	Expert Review Green;Literature	Spontaneous coronary artery dissection		Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	"Loeys-Dietz syndrome 2	MIM#610168"				32897753;35092149;36103205		False	3	100;0;0	0.56	True		ENSG00000163513	ENSG00000163513	HGNC:11773													
FLNA	gene	FLNA	Expert Review Amber;Literature	Spontaneous coronary artery dissection		Cardiovascular disorders	X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)	Spontaneous coronary artery dissection				29334594		False	2	0;100;0	0.56	True		ENSG00000196924	ENSG00000196924	HGNC:3754													
LOX	gene	LOX	Expert Review Amber;Literature	Spontaneous coronary artery dissection		Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	"Aortic aneurysm, familial thoracic 10	MIM#617168"				32897753;36103205		False	2	0;100;0	0.56	True		ENSG00000113083	ENSG00000113083	HGNC:6664													
MYLK	gene	MYLK	Expert Review Amber;Literature	Spontaneous coronary artery dissection		Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	"Aortic aneurysm, familial thoracic 7	MIM#613780"				33125268		False	2	0;100;0	0.56	True		ENSG00000065534	ENSG00000065534	HGNC:7590													
TGFBR1	gene	TGFBR1	Expert Review Amber;Radboud University Medical Center, Nijmegen	Spontaneous coronary artery dissection		Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	"Loeys-Dietz syndrome 1	MIM#609192"				35092149;36103205		False	2	0;100;0	0.56	True		ENSG00000106799	ENSG00000106799	HGNC:11772													
TLN1	gene	TLN1	Expert Review Amber;Literature	Spontaneous coronary artery dissection		Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	idiopathic spontaneous coronary artery dissection MONDO:0007385				30888838;36103205		False	2	0;100;0	0.56	True		ENSG00000137076	ENSG00000137076	HGNC:11845													
YY1AP1	gene	YY1AP1	Expert Review Amber;Literature	Spontaneous coronary artery dissection		Cardiovascular disorders	BIALLELIC, autosomal or pseudoautosomal	Grange syndrome, MIM# 602531				33125268		False	2	0;100;0	0.56	True		ENSG00000163374	ENSG00000163374	HGNC:30935													
LMX1B	gene	LMX1B	Expert Review Red;Literature	Spontaneous coronary artery dissection		Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	"Nail-patella syndrome	MIM#161200"				29650765		False	1	0;50;50	0.56	True		ENSG00000136944	ENSG00000136944	HGNC:6654													
PKD1	gene	PKD1	Expert Review Red;Literature	Spontaneous coronary artery dissection		Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	"Polycystic kidney disease 1	MIM#173900"				35630097;26798684;26971055;29650765		False	1	50;0;50	0.56	True		ENSG00000008710	ENSG00000008710	HGNC:9008													
PTGIR	gene	PTGIR	Expert Review Red;Literature	Spontaneous coronary artery dissection		Cardiovascular disorders	Unknown					32531060		False	1	0;0;100	0.56	True		ENSG00000160013	ENSG00000160013	HGNC:9602													
TSR1	gene	TSR1	Expert Review Red;Literature	Spontaneous coronary artery dissection		Cardiovascular disorders	Unknown					PMID: 31296288;31296287;37979122		False	1	0;0;100	0.56	True		ENSG00000167721	ENSG00000167721	HGNC:25542