Transplant Co-Morbidity Superpanel
Gene: TPMT

TPMT (thiopurine S-methyltransferase)
EnsemblGeneIds (GRCh38): ENSG00000137364
EnsemblGeneIds (GRCh37): ENSG00000137364
OMIM: 187680, Gene2Phenotype
TPMT is in 4 panels

1 review

Claire Fryer-Smith (University of Melbourne)

Green List (high evidence)

Alleles in TPMT are in guidelines for thiopurines including mercaptopurine and azathioprine.

https://www.pharmgkb.org/gene/PA356
Sources: Expert list
Created: 24 Aug 2023, 4:33 a.m.

Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Phenotypes
Thiopurines, poor metabolism of, 1 MIM# 610460

Created: 24 Aug 2023, 4:33 a.m.

Panel version: 0.4

Details

Mode of Inheritance

BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Sources

Expert Review Green

Phenotypes

Thiopurines, poor metabolism of, 1 MIM# 610460

OMIM

187680

Clinvar variants

Variants in TPMT

Penetrance

None

Panels with this gene

History Filter Activity

28 Aug 2023, Gel status: 3

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: tpmt has been classified as Green List (High Evidence).

24 Aug 2023, Gel status: 0

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Claire Fryer-Smith (University of Melbourne)

gene: TPMT was added gene: TPMT was added to Transplant Co-Morbidity Superpanel. Sources: Expert list Mode of inheritance for gene: TPMT was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal Phenotypes for gene: TPMT were set to Thiopurines, poor metabolism of, 1 MIM# 610460 Review for gene: TPMT was set to GREEN

Transplant Co-Morbidity Superpanel Gene: TPMT