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  3. CYP3A5
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Transplant Co-Morbidity Superpanel

Gene: CYP3A5

Green List (high evidence)
CYP3A5 (cytochrome P450 family 3 subfamily A member 5)
EnsemblGeneIds (GRCh38): ENSG00000106258
EnsemblGeneIds (GRCh37): ENSG00000106258
OMIM: 605325, Gene2Phenotype
CYP3A5 is in 2 panels

1 review

Claire Fryer-Smith (University of Melbourne)

Green List (high evidence)

Involved in guidelines for tacrolimus.
CYP3A5 expression has extreme interpopulation variability.
Allelic variants at locus increases susceptibility to hypertension.

https://www.pharmgkb.org/gene/PA131/overview
Sources: Expert list
Created: 24 Aug 2023, 4:43 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Hypertension, salt-sensitive essential, susceptibility to MIM#145500

Created: 24 Aug 2023, 4:43 a.m.

Panel version: 0.4

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
Phenotypes
  • Hypertension, salt-sensitive essential, susceptibility to MIM#145500
OMIM
605325
Clinvar variants
Variants in CYP3A5
Penetrance
None
Panels with this gene

History Filter Activity

28 Aug 2023, Gel status: 3

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: cyp3a5 has been classified as Green List (High Evidence).

28 Aug 2023, Gel status: 3

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: cyp3a5 has been classified as Green List (High Evidence).

24 Aug 2023, Gel status: 0

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Claire Fryer-Smith (University of Melbourne)

gene: CYP3A5 was added gene: CYP3A5 was added to Transplant Co-Morbidity Superpanel. Sources: Expert list Mode of inheritance for gene: CYP3A5 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: CYP3A5 were set to Hypertension, salt-sensitive essential, susceptibility to MIM#145500 Review for gene: CYP3A5 was set to GREEN