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BabyScreen+ newborn screening

Gene: IL10

Green List (high evidence)

IL10 (interleukin 10)
EnsemblGeneIds (GRCh38): ENSG00000136634
EnsemblGeneIds (GRCh37): ENSG00000136634
OMIM: 124092, Gene2Phenotype
IL10 is in 6 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Established gene-disease association.

Onset in infancy and childhood.

Treatment: BMT

Non-genetic confirmatory testing: flow cytometry
Sources: Expert list
Created: 4 Oct 2023, 2:31 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Autoinflammatory syndrome, MONDO:0019751, IL10-related

Publications

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • Autoinflammatory syndrome, MONDO:0019751, IL10-related
Tags
treatable immunological
OMIM
124092
Clinvar variants
Variants in IL10
Penetrance
None
Publications
Panels with this gene

History Filter Activity

4 Oct 2023, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: il10 has been classified as Green List (High Evidence).

4 Oct 2023, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: il10 has been classified as Green List (High Evidence).

4 Oct 2023, Gel status: 1

Added Tag, Added Tag

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Tag treatable tag was added to gene: IL10. Tag immunological tag was added to gene: IL10.

4 Oct 2023, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: IL10 was added gene: IL10 was added to BabyScreen+ newborn screening. Sources: Expert list Mode of inheritance for gene: IL10 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: IL10 were set to 22236434; 20951137; 19890111 Phenotypes for gene: IL10 were set to Autoinflammatory syndrome, MONDO:0019751, IL10-related Review for gene: IL10 was set to GREEN