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BabyScreen+ newborn screening

Gene: F10

Green List (high evidence)

F10 (coagulation factor X)
EnsemblGeneIds (GRCh38): ENSG00000126218
EnsemblGeneIds (GRCh37): ENSG00000126218
OMIM: 613872, Gene2Phenotype
F10 is in 5 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Well established gene-disease association.

Affected individuals can manifest prolonged nasal and mucosal haemorrhage, menorrhagia, haematuria, and occasionally hemarthrosis.

Treatment: plasma-derived factor 10 concentrate (Coagadex)
Created: 21 Nov 2022, 3:34 a.m. | Last Modified: 4 Oct 2023, 2:01 a.m.
Panel Version: 1.56

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Factor X deficiency, MIM# 227600

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • Factor X deficiency, MIM# 227600
Tags
treatable haematological
OMIM
613872
Clinvar variants
Variants in F10
Penetrance
None
Panels with this gene

History Filter Activity

4 Oct 2023, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: f10 has been classified as Green List (High Evidence).

4 Oct 2023, Gel status: 2

Removed Tag, Added Tag, Added Tag

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Tag for review was removed from gene: F10. Tag treatable tag was added to gene: F10. Tag haematological tag was added to gene: F10.

21 Nov 2022, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: f10 has been classified as Amber List (Moderate Evidence).

21 Nov 2022, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: f10 has been classified as Amber List (Moderate Evidence).

21 Nov 2022, Gel status: 3

Added Tag

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Tag for review tag was added to gene: F10.

18 Sep 2022, Gel status: 3

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: F10 was added gene: F10 was added to gNBS. Sources: Expert list,Expert Review Green Mode of inheritance for gene: F10 was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: F10 were set to Factor X deficiency, MIM# 227600