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Prepair 1000+

Gene: TRAC

Red List (low evidence)
TRAC (T-cell receptor alpha constant)
EnsemblGeneIds (GRCh38): ENSG00000277734
EnsemblGeneIds (GRCh37): ENSG00000229164
OMIM: 186880, Gene2Phenotype
TRAC is in 5 panels

3 reviews

Michelle Torres (Victorian Clinical Genetics Services)

Red List (low evidence)

The technical issues persist with Emedgene, remains red for Prepair.
Created: 21 Jan 2025, 12:49 a.m. | Last Modified: 21 Jan 2025, 12:49 a.m.
Panel Version: 1.1257

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Immunodeficiency 7, TCR-alpha/beta deficient MIM#615387

Created: 21 Jan 2025, 12:49 a.m.
Last Modified: 21 Jan 2025, 12:49 a.m.
Panel version: 1.1257

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Red List (low evidence)

Insufficient evidence for gene-disease association and note technical issues in data analysis.
Created: 18 Aug 2022, 6:10 a.m. | Last Modified: 18 Aug 2022, 6:10 a.m.
Panel Version: 0.137

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Immunodeficiency 7, TCR-alpha/beta deficient (MIM#615387)

Created: 18 Aug 2022, 6:10 a.m.
Last Modified: 18 Aug 2022, 6:10 a.m.
Panel version: 0.137

Crystle Lee (Victorian Clinical Genetics Services)

Red List (low evidence)

This gene has been removed from the final gene list version with the comment "annotation issues in Alissa". This gene is not recognised in Alissa, a "region" has to be entered instead of gene name.

Single variant reported to date in 6 patients; 2 unrelated children from consanguineous families of Pakistani descent (PMID: 21206088); 1 non-consanguineous family from North-west India (PMID: 33909184) and 1 consanguineous parents of East Indian (https://lymphosign.com/doi/10.14785/lymphosign-2022-0001)
Created: 14 Jul 2022, 3:28 a.m. | Last Modified: 14 Jul 2022, 3:28 a.m.
Panel Version: 0.40

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Immunodeficiency 7, TCR-alpha/beta deficient (MIM#615387)

Publications

Created: 14 Jul 2022, 3:28 a.m.
Last Modified: 14 Jul 2022, 3:28 a.m.
Panel version: 0.40

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Red
  • Mackenzie's Mission
Phenotypes
  • Immunodeficiency 7, TCR-alpha/beta deficient, 615387 (3)
OMIM
186880
Clinvar variants
Variants in TRAC
Penetrance
None
Panels with this gene

History Filter Activity

18 Aug 2022, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: trac has been classified as Red List (Low Evidence).

18 Aug 2022, Gel status: 1

Removed Tag

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Tag for review was removed from gene: TRAC.

18 Aug 2022, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: trac has been classified as Red List (Low Evidence).

14 Jul 2022, Gel status: 2

Added Tag

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Tag for review tag was added to gene: TRAC.

1 Jun 2022, Gel status: 2

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: TRAC was added gene: TRAC was added to Reproductive Carrier Screen_VCGS. Sources: Expert Review Amber,Mackenzie's Mission Mode of inheritance for gene: TRAC was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: TRAC were set to Immunodeficiency 7, TCR-alpha/beta deficient, 615387 (3)