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  3. MYT1L
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Severe early-onset obesity

Gene: MYT1L

Green List (high evidence)
MYT1L (myelin transcription factor 1 like)
EnsemblGeneIds (GRCh38): ENSG00000186487
EnsemblGeneIds (GRCh37): ENSG00000186487
OMIM: 613084, Gene2Phenotype
MYT1L is in 7 panels

1 review

Ain Roesley (Victorian Clinical Genetics Services)

Green List (high evidence)

>20 probands reported with syndromic obesity
Created: 1 Nov 2021, 12:24 a.m. | Last Modified: 1 Nov 2021, 12:24 a.m.
Panel Version: 0.22

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Intellectual disability and obesity (MIM#616521)

Publications

Variants in this GENE are reported as part of current diagnostic practice

Created: 1 Nov 2021, 12:24 a.m.
Last Modified: 1 Nov 2021, 12:24 a.m.
Panel version: 0.22

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Genomics England PanelApp
Phenotypes
  • Mental retardation, autosomal dominant 39, MIM# 616521
  • Obesity
Tags
SV/CNV
OMIM
613084
Clinvar variants
Variants in MYT1L
Penetrance
None
Publications
Panels with this gene

History Filter Activity

1 Nov 2021, Gel status: 3

Added Tag

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Tag SV/CNV tag was added to gene: MYT1L.

1 Nov 2021, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: myt1l has been classified as Green List (High Evidence).

1 Nov 2021, Gel status: 3

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: MYT1L were changed from obesity; Mental retardation, autosomal dominant 39, OMIM:616521 to Mental retardation, autosomal dominant 39, MIM# 616521; Obesity

1 Nov 2021, Gel status: 3

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: MYT1L were set to 25232846; 21990140; 25126114; 26240977; 24129437

31 Oct 2021, Gel status: 3

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: MYT1L was added gene: MYT1L was added to Severe early-onset obesity. Sources: Genomics England PanelApp,Expert Review Green Mode of inheritance for gene: MYT1L was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: MYT1L were set to 25232846; 21990140; 25126114; 26240977; 24129437 Phenotypes for gene: MYT1L were set to obesity; Mental retardation, autosomal dominant 39, OMIM:616521