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Fetal anomalies

Gene: WNT10B

Green List (high evidence)

WNT10B (Wnt family member 10B)
EnsemblGeneIds (GRCh38): ENSG00000169884
EnsemblGeneIds (GRCh37): ENSG00000169884
OMIM: 601906, Gene2Phenotype
WNT10B is in 7 panels

1 review

Alison Yeung (Victorian Clinical Genetics Services)

Green List (high evidence)

Biallelic variants associated with Split hand/foot malformation. Reported in >3 unrelated families, with a Pakistani bias.
Detectable on antenatal US
Created: 20 Dec 2021, 6:41 a.m. | Last Modified: 20 Dec 2021, 6:41 a.m.
Panel Version: 0.1538

Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Phenotypes
Split-hand/foot malformation 6, OMIM #601906

Publications

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Genomics England PanelApp
Phenotypes
  • Split-hand/foot malformation 6, OMIM:225300
OMIM
601906
Clinvar variants
Variants in WNT10B
Penetrance
None
Publications
Panels with this gene

History Filter Activity

20 Dec 2021, Gel status: 3

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: WNT10B were set to

20 Dec 2021, Gel status: 3

Entity classified by Genomics England curator

Alison Yeung (Victorian Clinical Genetics Services)

Gene: wnt10b has been classified as Green List (High Evidence).

20 Dec 2021, Gel status: 3

Entity classified by Genomics England curator

Alison Yeung (Victorian Clinical Genetics Services)

Gene: wnt10b has been classified as Green List (High Evidence).

24 Oct 2021, Gel status: 3

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: WNT10B was added gene: WNT10B was added to Fetal anomalies. Sources: Expert Review Green,Genomics England PanelApp Mode of inheritance for gene: WNT10B was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: WNT10B were set to Split-hand/foot malformation 6, OMIM:225300