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Fetal anomalies

Gene: MGP

Green List (high evidence)

MGP (matrix Gla protein)
EnsemblGeneIds (GRCh38): ENSG00000111341
EnsemblGeneIds (GRCh37): ENSG00000111341
OMIM: 154870, Gene2Phenotype
MGP is in 9 panels

2 reviews

Alison Yeung (Victorian Clinical Genetics Services)

Green List (high evidence)

Keutel syndrome is an autosomal recessive disorder characterized by multiple peripheral pulmonary stenoses, brachytelephalangy, inner ear deafness, and abnormal cartilage ossification or calcification. Skeletal changes and cartilage ossification may be visible on fetal ultrasound.
Created: 28 Jan 2022, 12:11 a.m. | Last Modified: 28 Jan 2022, 12:11 a.m.
Panel Version: 0.2843

Chirag Patel (Genetic Health Queensland)

Red List (low evidence)

No ID in this syndrome.
Created: 5 Dec 2019, 1:02 a.m. | Last Modified: 5 Dec 2019, 1:02 a.m.
Panel Version: 0.423

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Keutel syndrome; OMIM #245150

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Genomics England PanelApp
  • Expert list
Phenotypes
  • Keutel syndrome, MIM #245150
OMIM
154870
Clinvar variants
Variants in MGP
Penetrance
None
Panels with this gene

History Filter Activity

28 Jan 2022, Gel status: 3

Entity classified by Genomics England curator

Alison Yeung (Victorian Clinical Genetics Services)

Gene: mgp has been classified as Green List (High Evidence).

28 Jan 2022, Gel status: 3

Set Phenotypes

Alison Yeung (Victorian Clinical Genetics Services)

Phenotypes for gene: MGP were changed from KEUTEL SYNDROME to Keutel syndrome, MIM #245150

24 Oct 2021, Gel status: 3

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: MGP was added gene: MGP was added to Fetal anomalies. Sources: Expert Review Green,Genomics England PanelApp Mode of inheritance for gene: MGP was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: MGP were set to KEUTEL SYNDROME