Miscellaneous Metabolic Disorders

Gene: TDO2

Red List (low evidence)

TDO2 (tryptophan 2,3-dioxygenase)
EnsemblGeneIds (GRCh38): ENSG00000151790
EnsemblGeneIds (GRCh37): ENSG00000151790
OMIM: 191070, Gene2Phenotype
TDO2 is in 3 panels

1 review

Bryony Thompson (Royal Melbourne Hospital)

Red List (low evidence)

Single case reported, biochemical phenotype of hypertryptophanemia and hyperserotoninemia does not appear to have significant clinical consequences
Sources: Literature
Created: 8 Feb 2021, 2:57 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Hypertryptophanemia MIM#600627; Disorders of histidine, tryptophan or lysine metabolism

Publications

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Red
  • Literature
Phenotypes
  • Hypertryptophanemia MIM#600627
  • Disorders of histidine, tryptophan or lysine metabolism
OMIM
191070
Clinvar variants
Variants in TDO2
Penetrance
None
Publications
Panels with this gene

History Filter Activity

8 Feb 2021, Gel status: 1

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: tdo2 has been classified as Red List (Low Evidence).

8 Feb 2021, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Bryony Thompson (Royal Melbourne Hospital)

gene: TDO2 was added gene: TDO2 was added to Miscellaneous Metabolic Disorders. Sources: Literature Mode of inheritance for gene: TDO2 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: TDO2 were set to 28285122; 27604308 Phenotypes for gene: TDO2 were set to Hypertryptophanemia MIM#600627; Disorders of histidine, tryptophan or lysine metabolism Review for gene: TDO2 was set to RED