Miscellaneous Metabolic Disorders
Gene: TDO2

TDO2 (tryptophan 2,3-dioxygenase)
EnsemblGeneIds (GRCh38): ENSG00000151790
EnsemblGeneIds (GRCh37): ENSG00000151790
OMIM: 191070, Gene2Phenotype
TDO2 is in 3 panels

1 review

Bryony Thompson (Royal Melbourne Hospital)

Red List (low evidence)

Single case reported, biochemical phenotype of hypertryptophanemia and hyperserotoninemia does not appear to have significant clinical consequences
Sources: Literature
Created: 8 Feb 2021, 2:57 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Hypertryptophanemia MIM#600627; Disorders of histidine, tryptophan or lysine metabolism

Publications

Created: 8 Feb 2021, 2:57 a.m.

Panel version: 0.309

Details

Mode of Inheritance

BIALLELIC, autosomal or pseudoautosomal

Sources

Expert Review Red
Literature

Phenotypes

Hypertryptophanemia MIM#600627
Disorders of histidine, tryptophan or lysine metabolism

OMIM

191070

Clinvar variants

Variants in TDO2

Penetrance

None

Publications

Panels with this gene

History Filter Activity

8 Feb 2021, Gel status: 1

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: tdo2 has been classified as Red List (Low Evidence).

8 Feb 2021, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes