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  3. SUGCT
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Miscellaneous Metabolic Disorders

Gene: SUGCT

Amber List (moderate evidence)
SUGCT (succinyl-CoA:glutarate-CoA transferase)
EnsemblGeneIds (GRCh38): ENSG00000175600
EnsemblGeneIds (GRCh37): ENSG00000175600
OMIM: 609187, Gene2Phenotype
SUGCT is in 3 panels

1 review

Bryony Thompson (Royal Melbourne Hospital)

Green List (high evidence)

Comment on list classification: Likely benign condition
Created: 8 Feb 2021, 12:29 a.m. | Last Modified: 8 Feb 2021, 12:29 a.m.
Panel Version: 0.300
At least 10 cases reported with glutaric aciduria 3. There is insufficient evidence to define any specific clinical phenotype as attributable to GA3. GA3 is a naturally occurring biochemical trait in mouse models.
Sources: Literature
Created: 8 Feb 2021, 12:28 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Glutaric aciduria III MIM#231690; Organic acidurias

Publications

Created: 8 Feb 2021, 12:28 a.m.

Panel version: 0.299

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Amber
  • Literature
Phenotypes
  • Glutaric aciduria III MIM#231690
  • Organic acidurias
OMIM
609187
Clinvar variants
Variants in SUGCT
Penetrance
None
Publications
Panels with this gene

History Filter Activity

8 Feb 2021, Gel status: 2

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: sugct has been classified as Amber List (Moderate Evidence).

8 Feb 2021, Gel status: 2

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: sugct has been classified as Amber List (Moderate Evidence).

8 Feb 2021, Gel status: 1

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: sugct has been classified as Red List (Low Evidence).

8 Feb 2021, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Bryony Thompson (Royal Melbourne Hospital)

gene: SUGCT was added gene: SUGCT was added to Miscellaneous Metabolic Disorders. Sources: Literature Mode of inheritance for gene: SUGCT was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: SUGCT were set to 28766179; 18926513; 33483254; 32779420; 27604308 Phenotypes for gene: SUGCT were set to Glutaric aciduria III MIM#231690; Organic acidurias Review for gene: SUGCT was set to GREEN