Pharmacogenomics_Paediatric
Gene: TPMTIn newborn infants, peripheral blood TPMT activity is 50% greater than in race-matched adults and shows a distribution of activity consistent with the polymorphism characterized in adults.Created: 23 Aug 2020, 3:32 a.m. | Last Modified: 23 Aug 2020, 3:32 a.m.
Panel Version: 0.49
Azathioprine; Mercaptopurine; ThioguaninesCreated: 14 Aug 2020, 4:32 a.m. | Last Modified: 14 Aug 2020, 4:32 a.m.
Panel Version: 0.33
Sources: Expert listCreated: 31 Jul 2020, 10:10 a.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
{Thiopurines, poor metabolism of, 1}, MIM# 610460; Azathioprine; Mercaptopurine
Publications
Phenotypes for gene: TPMT were changed from {Thiopurines, poor metabolism of, 1}, MIM# 610460; Azathioprine; Mercaptopurine to {Thiopurines, poor metabolism of, 1}, MIM# 610460; Azathioprine; Mercaptopurine; Thioguanines
Publications for gene: TPMT were set to
Phenotypes for gene: TPMT were changed from {Thiopurines, poor metabolism of, 1}, MIM# 610460; Azathioprine to {Thiopurines, poor metabolism of, 1}, MIM# 610460; Azathioprine; Mercaptopurine
Gene: tpmt has been classified as Green List (High Evidence).
Gene: tpmt has been classified as Green List (High Evidence).
gene: TPMT was added gene: TPMT was added to Pharmacogenomics_Paediatric. Sources: Expert list Mode of inheritance for gene: TPMT was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: TPMT were set to {Thiopurines, poor metabolism of, 1}, MIM# 610460; Azathioprine Review for gene: TPMT was set to GREEN