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  3. NUDT15
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Pharmacogenomics_Paediatric

Gene: NUDT15

Green List (high evidence)
NUDT15 (nudix hydrolase 15)
EnsemblGeneIds (GRCh38): ENSG00000136159
EnsemblGeneIds (GRCh37): ENSG00000136159
OMIM: 615792, Gene2Phenotype
NUDT15 is in 2 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Sources: Expert list
Created: 31 Jul 2020, 10:18 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
{Thiopurines, poor metabolism of, 2} 616903; Azathioprine; Mercaptopurine

Publications

Created: 31 Jul 2020, 10:18 a.m.

Panel version: 0.25

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • {Thiopurines, poor metabolism of, 2} 616903
  • Azathioprine
  • Mercaptopurine
OMIM
615792
Clinvar variants
Variants in NUDT15
Penetrance
None
Publications
Panels with this gene

History Filter Activity

1 Aug 2020, Gel status: 3

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: NUDT15 were set to

1 Aug 2020, Gel status: 3

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: NUDT15 were changed from {Thiopurines, poor metabolism of, 2} 616903; Azathioprine to {Thiopurines, poor metabolism of, 2} 616903; Azathioprine; Mercaptopurine

31 Jul 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: nudt15 has been classified as Green List (High Evidence).

31 Jul 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: nudt15 has been classified as Green List (High Evidence).

31 Jul 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: NUDT15 was added gene: NUDT15 was added to Pharmacogenomics_Paediatric. Sources: Expert list Mode of inheritance for gene: NUDT15 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: NUDT15 were set to {Thiopurines, poor metabolism of, 2} 616903; Azathioprine Review for gene: NUDT15 was set to GREEN