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Pharmacogenomics_Paediatric

Gene: HLA-B

Green List (high evidence)
HLA-B (major histocompatibility complex, class I, B)
EnsemblGeneIds (GRCh38): ENSG00000234745
EnsemblGeneIds (GRCh37): ENSG00000234745
OMIM: 142830, Gene2Phenotype
HLA-B is in 2 panels

2 reviews

David Metz (Royal Children's Hospital)


HLA-B*15:02:
Increased carbamazepine-induced SJS/TEN (CPIC guideline, 29392710).
Increase oxcarbazepine-induced SJS/TEN (CPIC guideline, 29392710).
Increased lamotrogine-induced SJS/TEN (meta-analysis, 25428396).
Increased phenytoin-induced SJS/TEN (25099164).

PMID 26094938
HLA-B*58:01 and allopurinol-induced SJS/TEN

PMID: 23232549
Carrier of HLA-B*5801 (HLA-B*5801/*X,b HLA-B*5801/HLA-B*5801), significant increase in risk of allopurinol induced SCAR (severe cutaneous adverse reaction).

HLA-B*5701 and Abacavir hypersensitivity.
25934581, 22378157

HLA-B*5701-positive patients have an 80-fold elevated risk of flucloxacillin-induced liver injury. However, the incidence is low (1-2 per 1000 individuals).
https://www.pharmgkb.org/chemical/PA164781042/guidelineAnnotation/PA166182810

PMID 32714190 (review article)
HLA-B*57:01, carbamazepine and SJS/TEN.
HLA-B*15:11, carbamazepine and SJS/TEN.

HLA-B*13:01, dapsone and DRESS (29458119)
Created: 14 Aug 2020, 2:07 a.m. | Last Modified: 21 Sep 2020, 1:17 a.m.
Panel Version: 0.50

Publications

Created: 14 Aug 2020, 2:03 a.m.
Last Modified: 21 Sep 2020, 1:17 a.m.
Panel version: 0.33

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

HLA-B*1502
Sources: Expert list
Created: 31 Jul 2020, 10:16 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Carbamazepine; Oxcarbamazepine; Phenytoin

Publications

Created: 31 Jul 2020, 10:16 a.m.

Panel version: 0.27

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • Carbamazepine
  • Oxcarbamazepine
  • Phenytoin
OMIM
142830
Clinvar variants
Variants in HLA-B
Penetrance
None
Publications
Panels with this gene

History Filter Activity

14 Aug 2020, Gel status: 3

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: HLA-B were set to 25099164; 23695185; 29392710

1 Aug 2020, Gel status: 3

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: HLA-B were set to 25099164; 23695185

1 Aug 2020, Gel status: 3

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: HLA-B were set to 25099164

1 Aug 2020, Gel status: 3

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: HLA-B were set to

31 Jul 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: hla-b has been classified as Green List (High Evidence).

31 Jul 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: hla-b has been classified as Green List (High Evidence).

31 Jul 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: HLA-B was added gene: HLA-B was added to Pharmacogenomics_Paediatric. Sources: Expert list Mode of inheritance for gene: HLA-B was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: HLA-B were set to Carbamazepine; Oxcarbamazepine; Phenytoin Review for gene: HLA-B was set to GREEN