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  3. CYP3A5
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Pharmacogenomics_Paediatric

Gene: CYP3A5

Green List (high evidence)
CYP3A5 (cytochrome P450 family 3 subfamily A member 5)
EnsemblGeneIds (GRCh38): ENSG00000106258
EnsemblGeneIds (GRCh37): ENSG00000106258
OMIM: 605325, Gene2Phenotype
CYP3A5 is in 2 panels

2 reviews

David Metz (Royal Children's Hospital)

Reduced bioavailability/clearance of tacrolimus.
Association with negative outcomes in kidney transplantation.
Created: 14 Aug 2020, 12:57 a.m. | Last Modified: 14 Aug 2020, 12:57 a.m.
Panel Version: 0.33

Publications

Created: 14 Aug 2020, 12:12 a.m.
Last Modified: 14 Aug 2020, 12:12 a.m.
Panel version: 0.33

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Sources: Expert list
Created: 31 Jul 2020, 10:14 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Tacrolimus

Publications

Created: 31 Jul 2020, 10:14 a.m.

Panel version: 0.29

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • Tacrolimus
OMIM
605325
Clinvar variants
Variants in CYP3A5
Penetrance
None
Publications
Panels with this gene

History Filter Activity

14 Aug 2020, Gel status: 3

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: CYP3A5 were set to 25801146

1 Aug 2020, Gel status: 3

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: CYP3A5 were set to

31 Jul 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: cyp3a5 has been classified as Green List (High Evidence).

31 Jul 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: cyp3a5 has been classified as Green List (High Evidence).

31 Jul 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: CYP3A5 was added gene: CYP3A5 was added to Pharmacogenomics_Paediatric. Sources: Expert list Mode of inheritance for gene: CYP3A5 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: CYP3A5 were set to Tacrolimus Review for gene: CYP3A5 was set to GREEN