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  3. CYP2D6
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Pharmacogenomics_Paediatric

Gene: CYP2D6

Green List (high evidence)
CYP2D6 (cytochrome P450 family 2 subfamily D member 6)
EnsemblGeneIds (GRCh38): ENSG00000100197
EnsemblGeneIds (GRCh37): ENSG00000100197
OMIM: 124030, Gene2Phenotype
CYP2D6 is in 2 panels

2 reviews

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Phenotypes
Codeine, tramadol, oxycodone

Publications

Created: 14 Aug 2020, 8:46 a.m.
Last Modified: 14 Aug 2020, 8:46 a.m.
Panel version: 0.36

David Metz (Royal Children's Hospital)

PMID: 18406467
Genotype-phenotype concordance from 2 weeks of age

PMID: 24458010
Strong evidence. Risk of toxicity from codeine, tramadol, (oxycodone) if ultrarapid metaboliser.
Insensitivity to codeine, tramadol, (oxycodone) if poor metaboliser.
Created: 14 Aug 2020, 12:31 a.m. | Last Modified: 14 Aug 2020, 4:18 a.m.
Panel Version: 0.33

Mode of inheritance
Other

Publications

Created: 14 Aug 2020, 12:31 a.m.
Last Modified: 14 Aug 2020, 4:18 a.m.
Panel version: 0.33

Details

Mode of Inheritance
Other
Sources
  • Expert Review Green
Phenotypes
  • Codeine, tramadol, oxycodone
OMIM
124030
Clinvar variants
Variants in CYP2D6
Penetrance
None
Publications
Panels with this gene

History Filter Activity

14 Aug 2020, Gel status: 3

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: CYP2D6 were set to 18406467

14 Aug 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: cyp2d6 has been classified as Green List (High Evidence).

14 Aug 2020, Gel status: 3

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: CYP2D6 were changed from to Codeine, tramadol, oxycodone

14 Aug 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: cyp2d6 has been classified as Green List (High Evidence).

14 Aug 2020, Gel status: 0

Created, Added New Source, Set mode of inheritance, Set publications

David Metz (Royal Children's Hospital)

gene: CYP2D6 was added gene: CYP2D6 was added to Pharmacogenomics_Paediatric. Sources: Other Mode of inheritance for gene: CYP2D6 was set to Other Publications for gene: CYP2D6 were set to 18406467