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  3. CYP2C19
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Pharmacogenomics_Paediatric

Gene: CYP2C19

Green List (high evidence)
CYP2C19 (cytochrome P450 family 2 subfamily C member 19)
EnsemblGeneIds (GRCh38): ENSG00000165841
EnsemblGeneIds (GRCh37): ENSG00000165841
OMIM: 124020, Gene2Phenotype
CYP2C19 is in 3 panels

2 reviews

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Phenotypes
Voriconazole

Publications

Created: 14 Aug 2020, 8:44 a.m.
Last Modified: 14 Aug 2020, 8:44 a.m.
Panel version: 0.34

David Metz (Royal Children's Hospital)

Voriconazole: Improved time to target concentration with genotype directed dosing (PMID 26616742), reduced underexposure (PMID: 31549389) (PMID 31549386)
Created: 14 Aug 2020, 2:16 a.m. | Last Modified: 14 Aug 2020, 2:19 a.m.
Panel Version: 0.33
(27981572)
Voriconazole, moderate strength.
Poor metabolizer: "Higher dose-adjusted trough concentrations of voriconazole and
may increase probability of adverse events."
Ultrarapid metabolizer: "probability of attainment of therapeutic voriconazole concentrations is small with standard dosing."
Created: 14 Aug 2020, 1:20 a.m. | Last Modified: 14 Aug 2020, 4:30 a.m.
Panel Version: 0.33

Mode of inheritance
Other

Publications

Created: 14 Aug 2020, 1:20 a.m.
Last Modified: 14 Aug 2020, 4:30 a.m.
Panel version: 0.33

Details

Mode of Inheritance
Other
Sources
  • Expert Review Green
Phenotypes
  • Voriconazole
OMIM
124020
Clinvar variants
Variants in CYP2C19
Penetrance
None
Publications
Panels with this gene

History Filter Activity

14 Aug 2020, Gel status: 3

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: CYP2C19 were set to 27981572

14 Aug 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: cyp2c19 has been classified as Green List (High Evidence).

14 Aug 2020, Gel status: 3

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: CYP2C19 were changed from to Voriconazole

14 Aug 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: cyp2c19 has been classified as Green List (High Evidence).

14 Aug 2020, Gel status: 0

Created, Added New Source, Set mode of inheritance, Set publications

David Metz (Royal Children's Hospital)

gene: CYP2C19 was added gene: CYP2C19 was added to Pharmacogenomics_Paediatric. Sources: Other Mode of inheritance for gene: CYP2C19 was set to Other Publications for gene: CYP2C19 were set to 27981572