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  2. Primary Ovarian Insufficiency_Premature Ovarian Failure
  3. WRN
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Primary Ovarian Insufficiency_Premature Ovarian Failure

Gene: WRN

Green List (high evidence)
WRN (Werner syndrome RecQ like helicase)
EnsemblGeneIds (GRCh38): ENSG00000165392
EnsemblGeneIds (GRCh37): ENSG00000165392
OMIM: 604611, Gene2Phenotype
WRN is in 14 panels

1 review

Bryony Thompson (Royal Melbourne Hospital)

Green List (high evidence)

Hypogonadism is a prominent feature of the condition, reportedly present in ~80% of cases.
Sources: Literature
Created: 6 Dec 2021, 3:57 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Werner syndrome MIM#277700

Publications

Variants in this GENE are reported as part of current diagnostic practice

Created: 6 Dec 2021, 3:57 a.m.

Panel version: 0.265

History Filter Activity

6 Dec 2021, Gel status: 3

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: wrn has been classified as Green List (High Evidence).

6 Dec 2021, Gel status: 3

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: wrn has been classified as Green List (High Evidence).

6 Dec 2021, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Bryony Thompson (Royal Melbourne Hospital)

gene: WRN was added gene: WRN was added to Primary Ovarian Insufficiency_Premature Ovarian Failure. Sources: Literature Mode of inheritance for gene: WRN was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: WRN were set to 34794894; 20301687 Phenotypes for gene: WRN were set to Werner syndrome MIM#277700 Review for gene: WRN was set to GREEN gene: WRN was marked as current diagnostic