Primary Ovarian Insufficiency_Premature Ovarian Failure

Gene: WEE2

Red List (low evidence)

WEE2 (WEE1 homolog 2)
EnsemblGeneIds (GRCh38): ENSG00000214102
EnsemblGeneIds (GRCh37): ENSG00000214102
OMIM: 614084, Gene2Phenotype
WEE2 is in 2 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Red List (low evidence)

Over 10 individuals reported, however presentation is with primary infertility rather than POI/POF.
Created: 11 Dec 2020, 4:18 a.m. | Last Modified: 11 Dec 2020, 4:18 a.m.
Panel Version: 0.109

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Oocyte maturation defect 5, MIM# 617996

Publications

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Red
  • Genetic Health QLD
Phenotypes
  • Oocyte maturation defect 5, MIM# 617996
OMIM
614084
Clinvar variants
Variants in WEE2
Penetrance
None
Publications
Panels with this gene

History Filter Activity

11 Dec 2020, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: wee2 has been classified as Red List (Low Evidence).

11 Dec 2020, Gel status: 1

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: WEE2 were changed from to Oocyte maturation defect 5, MIM# 617996

11 Dec 2020, Gel status: 1

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: WEE2 were set to

11 Dec 2020, Gel status: 1

Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Mode of inheritance for gene: WEE2 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal

11 Dec 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Bryony Thompson (Royal Melbourne Hospital)

gene: WEE2 was added gene: WEE2 was added to Primary Ovarian Insufficiency_Premature Ovarian Failure. Sources: Genetic Health QLD Mode of inheritance for gene: WEE2 was set to Unknown