1. Panels
  2. Primary Ovarian Insufficiency_Premature Ovarian Failure
  3. MEIOB
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Primary Ovarian Insufficiency_Premature Ovarian Failure

Gene: MEIOB

Amber List (moderate evidence)
MEIOB (meiosis specific with OB domains)
EnsemblGeneIds (GRCh38): ENSG00000162039
EnsemblGeneIds (GRCh37): ENSG00000162039
OMIM: 617670, Gene2Phenotype
MEIOB is in 2 panels

1 review

Bryony Thompson (Royal Melbourne Hospital)

I don't know

Single family with a homozygous splicing variant in 2 affected sisters. Female null mouse model is infertile.
Sources: Literature
Created: 6 Dec 2021, 12:38 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Primary ovarian insufficiency

Publications

Created: 6 Dec 2021, 12:38 a.m.

Panel version: 0.257

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Amber
  • Literature
Phenotypes
  • Primary ovarian insufficiency
OMIM
617670
Clinvar variants
Variants in MEIOB
Penetrance
None
Publications
Panels with this gene

History Filter Activity

6 Dec 2021, Gel status: 2

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: meiob has been classified as Amber List (Moderate Evidence).

6 Dec 2021, Gel status: 2

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: meiob has been classified as Amber List (Moderate Evidence).

6 Dec 2021, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Bryony Thompson (Royal Melbourne Hospital)

gene: MEIOB was added gene: MEIOB was added to Primary Ovarian Insufficiency_Premature Ovarian Failure. Sources: Literature Mode of inheritance for gene: MEIOB was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: MEIOB were set to 34794894; 24068956; 31000419 Phenotypes for gene: MEIOB were set to Primary ovarian insufficiency Review for gene: MEIOB was set to AMBER