1. Panels
  2. Primary Ovarian Insufficiency_Premature Ovarian Failure
  3. MCM8
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Primary Ovarian Insufficiency_Premature Ovarian Failure

Gene: MCM8

Green List (high evidence)
MCM8 (minichromosome maintenance 8 homologous recombination repair factor)
EnsemblGeneIds (GRCh38): ENSG00000125885
EnsemblGeneIds (GRCh37): ENSG00000125885
OMIM: 608187, Gene2Phenotype
MCM8 is in 2 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Three unrelated families reported.
Created: 18 May 2022, 1:16 a.m. | Last Modified: 18 May 2022, 1:16 a.m.
Panel Version: 0.297

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Premature ovarian failure 10, MIM# 612885

Publications

Created: 18 May 2022, 1:16 a.m.
Last Modified: 18 May 2022, 1:16 a.m.
Panel version: 0.297

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Royal Melbourne Hospital
Phenotypes
  • Premature ovarian failure 10, MIM# 612885
OMIM
608187
Clinvar variants
Variants in MCM8
Penetrance
None
Publications
Panels with this gene

History Filter Activity

18 May 2022, Gel status: 3

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: MCM8 were set to 32652893

3 Aug 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: mcm8 has been classified as Green List (High Evidence).

3 Aug 2020, Gel status: 3

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: MCM8 were set to

3 Aug 2020, Gel status: 3

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: MCM8 were changed from to Premature ovarian failure 10, MIM# 612885

17 Jun 2020, Gel status: 3

Created, Added New Source, Set mode of inheritance

Bryony Thompson (Royal Melbourne Hospital)

gene: MCM8 was added gene: MCM8 was added to Amenorrhoea. Sources: Royal Melbourne Hospital,Expert Review Green Mode of inheritance for gene: MCM8 was set to BIALLELIC, autosomal or pseudoautosomal