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  2. Primary Ovarian Insufficiency_Premature Ovarian Failure
  3. LHB
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Primary Ovarian Insufficiency_Premature Ovarian Failure

Gene: LHB

Green List (high evidence)
LHB (luteinizing hormone beta polypeptide)
EnsemblGeneIds (GRCh38): ENSG00000104826
EnsemblGeneIds (GRCh37): ENSG00000104826
OMIM: 152780, Gene2Phenotype
LHB is in 5 panels

1 review

Alison Yeung (Victorian Clinical Genetics Services)

Green List (high evidence)

Well established gene-disease association
Created: 28 Mar 2022, 2:10 a.m. | Last Modified: 28 Mar 2022, 2:10 a.m.
Panel Version: 0.291

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Created: 28 Mar 2022, 2:10 a.m.
Last Modified: 28 Mar 2022, 2:10 a.m.
Panel version: 0.291

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Royal Melbourne Hospital
Phenotypes
  • Hypogonadotropic hypogonadism 23 with or without anosmia, MIM# 228300
OMIM
152780
Clinvar variants
Variants in LHB
Penetrance
None
Panels with this gene

History Filter Activity

28 Mar 2022, Gel status: 3

Entity classified by Genomics England curator

Alison Yeung (Victorian Clinical Genetics Services)

Gene: lhb has been classified as Green List (High Evidence).

28 Mar 2022, Gel status: 3

Set Phenotypes

Alison Yeung (Victorian Clinical Genetics Services)

Phenotypes for gene: LHB were changed from to Hypogonadotropic hypogonadism 23 with or without anosmia, MIM# 228300

28 Mar 2022, Gel status: 3

Set mode of inheritance

Alison Yeung (Victorian Clinical Genetics Services)

Mode of inheritance for gene: LHB was changed from to BIALLELIC, autosomal or pseudoautosomal

17 Jun 2020, Gel status: 3

Created, Added New Source, Set mode of inheritance

Bryony Thompson (Royal Melbourne Hospital)

gene: LHB was added gene: LHB was added to Amenorrhoea. Sources: Royal Melbourne Hospital,Expert Review Green Mode of inheritance for gene: LHB was set to