Entity Name	Entity type	Gene Symbol	Sources(; separated)	Level4	Level3	Level2	Model_Of_Inheritance	Phenotypes	Omim	Orphanet	HPO	Publications	Description	Flagged	GEL_Status	UserRatings_Green_amber_red	version	ready	Mode of pathogenicity	EnsemblId(GRch37)	EnsemblId(GRch38)	HGNC	Position Chromosome	Position GRCh37 Start	Position GRCh37 End	Position GRCh38 Start	Position GRCh38 End	STR Repeated Sequence	STR Normal Repeats	STR Pathogenic Repeats	Region Haploinsufficiency Score	Region Triplosensitivity Score	Region Required Overlap Percentage	Region Variant Type	Region Verbose Name
ALG8	gene	ALG8	Expert list	Lymphoedema_syndromic	Lymphatic Disorders	Cardiovascular disorders	BIALLELIC, autosomal or pseudoautosomal				Lymphedema;HP:0001004	12480927;15235028		False	1	0;0;0	0.12	False		ENSG00000159063	ENSG00000159063	HGNC:23161													
ALX3	gene	ALX3	Expert Review Red;Radboud University Medical Center, Nijmegen;UKGTN	Lymphoedema_syndromic	Lymphatic Disorders	Cardiovascular disorders	BIALLELIC, autosomal or pseudoautosomal	Frontonasal dysplasia 1 136760			Lymphedema;HP:0001004	15127764		False	1	0;0;0	0.12	False		ENSG00000156150	ENSG00000156150	HGNC:449													
AQP1	gene	AQP1	Expert Review Red;Literature	Lymphoedema_syndromic	Lymphatic Disorders	Cardiovascular disorders	Unknown	[Blood group, Colton] 110450;Aquaporin-1 deficiency			Lymphedema;HP:0001004	11463012		False	1	0;0;0	0.12	False		ENSG00000240583	ENSG00000240583	HGNC:633													
CCDC88A	gene	CCDC88A	Expert Review Red;Literature	Lymphoedema_syndromic	Lymphatic Disorders	Cardiovascular disorders	BIALLELIC, autosomal or pseudoautosomal	?PEHO syndrome-like, 617507			Lymphedema;HP:0001004	26917597		False	1	0;0;0	0.12	False		ENSG00000115355	ENSG00000115355	HGNC:25523													
CDC42	gene	CDC42	Expert Review Red;Literature	Lymphoedema_syndromic	Lymphatic Disorders	Cardiovascular disorders	Unknown	Takenouchi-Kosaki syndrome 616737			Lymphedema;HP:0001004	26708094		False	1	0;0;0	0.12	False		ENSG00000070831	ENSG00000070831	HGNC:1736													
CHD7	gene	CHD7	Expert list;Expert Review Red	Lymphoedema_syndromic	Lymphatic Disorders	Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	CHARGE syndrome 214800			Lymphedema;HP:0001004	16155193;15300250;16400610		False	1	0;0;100	0.12	True		ENSG00000171316	ENSG00000171316	HGNC:20626													
FBXL7	gene	FBXL7	Expert Review Red;Literature	Lymphoedema_syndromic	Lymphatic Disorders	Cardiovascular disorders	BIALLELIC, autosomal or pseudoautosomal	Hennekam syndrome;lymphedema			Lymphedema;HP:0001004	31633297		False	1	0;0;100	0.12	True		ENSG00000183580	ENSG00000183580	HGNC:13604													
HGF	gene	HGF	Expert list	Lymphoedema_syndromic	Lymphatic Disorders	Cardiovascular disorders	Unknown				Lymphedema;HP:0001004	18564920		False	1	0;0;0	0.12	False		ENSG00000019991	ENSG00000019991	HGNC:4893													
MET	gene	MET	Expert list	Lymphoedema_syndromic	Lymphatic Disorders	Cardiovascular disorders	BOTH monoallelic and biallelic, autosomal or pseudoautosomal				Lymphedema;HP:0001004	18564920		False	1	0;0;0	0.12	False		ENSG00000105976	ENSG00000105976	HGNC:7029													
MPI	gene	MPI	Expert list	Lymphoedema_syndromic	Lymphatic Disorders	Cardiovascular disorders	BIALLELIC, autosomal or pseudoautosomal				Lymphedema;HP:0001004			False	1	0;0;0	0.12	False		ENSG00000178802	ENSG00000178802	HGNC:7216													
TTR	gene	TTR	Emory Genetics Laboratory;Expert Review Red;Illumina TruGenome Clinical Sequencing Services;Radboud University Medical Center, Nijmegen;UKGTN	Lymphoedema_syndromic	Lymphatic Disorders	Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	"Amyloidosis, hereditary, transthyretin-related 105210;Carpal tunnel syndrome, familial	115430;Dystransthyretinemic hyperthyroxinemia 145680"			Lymphedema;HP:0001004	31118583;30120737;31131842;31111153;30878017		False	1	0;0;0	0.12	False		ENSG00000118271	ENSG00000118271	HGNC:12405													
ZNHIT3	gene	ZNHIT3	Expert Review Red;Other	Lymphoedema_syndromic	Lymphatic Disorders	Cardiovascular disorders	BIALLELIC, autosomal or pseudoautosomal	PEHO syndrome, 260565			Lymphedema;HP:0001004	28335020		False	1	0;0;0	0.12	False		ENSG00000108278	ENSG00000273611	HGNC:12309