Monogenic Diabetes
Gene: LIPC
Established gene disease for association for hyperlipidemia (PMID: 1671786, 12777476, 1883393, 22798447)
No evidence of monogenic association with diabetes mellitus
PMID: 15126514: 490 subjects studied for -250G-A polymorphism in LIPC, 10.7% conversion rate with T2D, concluded associated as a risk factor for diabetes type 2
PMID: 18364377: 16,156 participants studied for -250G-A polymorphism, concluded no association T2D
PMID: 32617858: 2105 participants studied for -514C>T LIPC polymorphism, concluded no direct association T2DCreated: 9 May 2024, 2:55 a.m. | Last Modified: 9 May 2024, 2:55 a.m.
Panel Version: 0.107
Mode of inheritance
Unknown
Phenotypes
diabetes mellitus MONDO:0005015
Publications
Gene: lipc has been classified as Red List (Low Evidence).
Phenotypes for gene: LIPC were changed from {Diabetes mellitus, noninsulin-dependent}, 125853; [High density lipoprotein cholesterol level QTL 12], 612797; Hepatic lipase deficiency, 614025 to {Diabetes mellitus, noninsulin-dependent}, MIM#125853
Publications for gene: LIPC were set to
gene: LIPC was added gene: LIPC was added to Monogenic diabetes. Sources: Expert Review Red,Radboud University Medical Center, Nijmegen Mode of inheritance for gene: LIPC was set to Unknown Phenotypes for gene: LIPC were set to {Diabetes mellitus, noninsulin-dependent}, 125853; [High density lipoprotein cholesterol level QTL 12], 612797; Hepatic lipase deficiency, 614025