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  2. Monogenic Diabetes
  3. LIPC
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Monogenic Diabetes

Gene: LIPC

Red List (low evidence)
LIPC (lipase C, hepatic type)
EnsemblGeneIds (GRCh38): ENSG00000166035
EnsemblGeneIds (GRCh37): ENSG00000166035
OMIM: 151670, Gene2Phenotype
LIPC is in 6 panels

1 review

Hali Van Niel (University of Melbourne)

Red List (low evidence)

Established gene disease for association for hyperlipidemia (PMID: 1671786, 12777476, 1883393, 22798447)
No evidence of monogenic association with diabetes mellitus

PMID: 15126514: 490 subjects studied for -250G-A polymorphism in LIPC, 10.7% conversion rate with T2D, concluded associated as a risk factor for diabetes type 2
PMID: 18364377: 16,156 participants studied for -250G-A polymorphism, concluded no association T2D
PMID: 32617858: 2105 participants studied for -514C>T LIPC polymorphism, concluded no direct association T2D
Created: 9 May 2024, 2:55 a.m. | Last Modified: 9 May 2024, 2:55 a.m.
Panel Version: 0.107

Mode of inheritance
Unknown

Phenotypes
diabetes mellitus MONDO:0005015

Publications

Created: 9 May 2024, 2:55 a.m.
Last Modified: 9 May 2024, 2:55 a.m.
Panel version: 0.107

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Red
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • {Diabetes mellitus, noninsulin-dependent}, MIM#125853
OMIM
151670
Clinvar variants
Variants in LIPC
Penetrance
None
Publications
Panels with this gene

History Filter Activity

13 May 2024, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: lipc has been classified as Red List (Low Evidence).

13 May 2024, Gel status: 1

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: LIPC were changed from {Diabetes mellitus, noninsulin-dependent}, 125853; [High density lipoprotein cholesterol level QTL 12], 612797; Hepatic lipase deficiency, 614025 to {Diabetes mellitus, noninsulin-dependent}, MIM#125853

13 May 2024, Gel status: 1

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: LIPC were set to

17 Jan 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: LIPC was added gene: LIPC was added to Monogenic diabetes. Sources: Expert Review Red,Radboud University Medical Center, Nijmegen Mode of inheritance for gene: LIPC was set to Unknown Phenotypes for gene: LIPC were set to {Diabetes mellitus, noninsulin-dependent}, 125853; [High density lipoprotein cholesterol level QTL 12], 612797; Hepatic lipase deficiency, 614025