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  3. FOXC2
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Monogenic Diabetes

Gene: FOXC2

Red List (low evidence)
FOXC2 (forkhead box C2)
EnsemblGeneIds (GRCh38): ENSG00000176692
EnsemblGeneIds (GRCh37): ENSG00000176692
OMIM: 602402, Gene2Phenotype
FOXC2 is in 15 panels

1 review

Hali Van Niel (University of Melbourne)

I don't know

Well established gene disease associated for Lymphedema-distichiasis syndrome
Unclear if monogenic association for diabetes mellitus
PMID 15523639: report 4/6 affected family members also present with T2DM
PMID 27349002: low FOXC2 protein expression level with patients with T2DM, PMID 11551504: mouse model for insulin resistance
Created: 2 May 2024, 3:54 a.m. | Last Modified: 2 May 2024, 3:54 a.m.
Panel Version: 0.58

Mode of inheritance
Unknown

Phenotypes
lymphedema-distichiasis syndrome MONDO:0007922

Publications

Created: 2 May 2024, 3:54 a.m.
Last Modified: 2 May 2024, 3:54 a.m.
Panel version: 0.58

History Filter Activity

17 Jan 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: FOXC2 was added gene: FOXC2 was added to Monogenic diabetes. Sources: Expert Review Red,Radboud University Medical Center, Nijmegen Mode of inheritance for gene: FOXC2 was set to Unknown Phenotypes for gene: FOXC2 were set to Lymphedema-distichiasis syndrome, 153400; Lymphedema-distichiasis syndrome with renal disease and diabetes mellitus, 153400