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  2. Dystonia - complex
  3. GRN
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Dystonia - complex

Gene: GRN

Green List (high evidence)
GRN (granulin precursor)
EnsemblGeneIds (GRCh38): ENSG00000030582
EnsemblGeneIds (GRCh37): ENSG00000030582
OMIM: 138945, Gene2Phenotype
GRN is in 11 panels

1 review

Bryony Thompson (Royal Melbourne Hospital)

Green List (high evidence)

Dystonia is a reported feature of the phenotype
Sources: Expert list
Created: 30 Dec 2019, 11 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
Frontotemporal lobar degeneration with ubiquitin-positive inclusions, MIM#607485

Created: 30 Dec 2019, 11 a.m.

Panel version: 0.9

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • Frontotemporal lobar degeneration with ubiquitin-positive inclusions, MIM#607485
OMIM
138945
Clinvar variants
Variants in GRN
Penetrance
None
Panels with this gene

History Filter Activity

30 Dec 2019, Gel status: 3

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: grn has been classified as Green List (High Evidence).

30 Dec 2019, Gel status: 3

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: grn has been classified as Green List (High Evidence).

30 Dec 2019, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Bryony Thompson (Royal Melbourne Hospital)

gene: GRN was added gene: GRN was added to Dystonia - complex_RMH. Sources: Expert list Mode of inheritance for gene: GRN was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Phenotypes for gene: GRN were set to Frontotemporal lobar degeneration with ubiquitin-positive inclusions, MIM#607485 Review for gene: GRN was set to GREEN